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Complete Genome Sequence of Industrial Biocontrol Strain Paenibacillus polymyxa HY96-2 and Further Analysis of Its Biocontrol Mechanism

机译：工业生防菌多粘芽孢杆菌HY96-2的完整基因组序列及其生防机制的进一步分析

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Paenibacillus polymyxa (formerly known as Bacillus polymyxa) has been extensively studied for agricultural applications as a plant-growth-promoting rhizobacterium and is also an important biocontrol agent. Our team has developed the P. polymyxa strain HY96-2 from the tomato rhizosphere as the first microbial biopesticide based on P. polymyxa for controlling plant diseases around the world, leading to the commercialization of this microbial biopesticide in China. However, further research is essential for understanding its precise biocontrol mechanisms. In this paper, we report the complete genome sequence of HY96-2 and the results of a comparative genomic analysis between different P. polymyxa strains. The complete genome size of HY96-2 was found to be 5.75 Mb and 5207 coding sequences were predicted. HY96-2 was compared with seven other P. polymyxa strains for which complete genome sequences have been published, using phylogenetic tree, pan-genome, and nucleic acid co-linearity analysis. In addition, the genes and gene clusters involved in biofilm formation, antibiotic synthesis, and systemic resistance inducer production were compared between strain HY96-2 and two other strains, namely, SC2 and E681. The results revealed that all three of the P. polymyxa strains have the ability to control plant diseases via the mechanisms of colonization (biofilm formation), antagonism (antibiotic production), and induced resistance (systemic resistance inducer production). However, the variation of the corresponding genes or gene clusters between the three strains may lead to different antimicrobial spectra and biocontrol efficacies. Two possible pathways of biofilm formation in P. polymyxa were reported for the first time after searching the KEGG database. This study provides a scientific basis for the further optimization of the field applications and quality standards of industrial microbial biopesticides based on HY96-2. It may also serve as a reference for studying the differences in antimicrobial spectra and biocontrol capability between different biocontrol agents.
机译：多粘芽孢杆菌（Paenibacillus polymyxa）（以前称为多芽芽孢杆菌（Bacillus polymyxa））已作为用于植物生长的根瘤菌在农业上进行了广泛研究，并且也是重要的生物防治剂。我们的团队已经从番茄根际开发出了多粘毕生菌菌株HY96-2，作为第一种基于多粘毕生菌的微生物生物农药，用于控制世界各地的植物病害，从而使这种微生物生物农药在中国商业化。但是，进一步的研究对于了解其精确的生物防治机制至关重要。在本文中，我们报告了HY96-2的完整基因组序列，以及不同P. polymyxa菌株之间的比较基因组分析结果。发现HY96-2的完整基因组大小为5.75 Mb，并预测了5207个编码序列。使用系统树，泛基因组和核酸共线性分析，将HY96-2与其他七个已经公开了完整基因组序列的多粘菌进行了比较。此外，还比较了菌株HY96-2与其他两个菌株SC2和E681之间涉及生物膜形成，抗生素合成和系统抗性诱导剂产生的基因和基因簇。结果表明，所有三种体育粘液菌均具有通过定植（生物膜形成），拮抗作用（抗生素产生）和诱导抗性（系统性抗性诱导物产生）机制控制植物病害的能力。然而，三种菌株之间相应基因或基因簇的变异可能导致不同的抗菌谱和生物防治功效。在搜索KEGG数据库后，首次报道了多形黏液生物膜形成的两种可能途径。本研究为进一步优化基于HY96-2的工业微生物农药的现场应用和质量标准提供了科学依据。它也可以作为研究不同生物防治剂之间抗菌谱和生物防治能力差异的参考。

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