• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>other >Immune System Dysregulation During Spaceflight: Potential Countermeasures for Deep Space Exploration Missions
【2h】

Immune System Dysregulation During Spaceflight: Potential Countermeasures for Deep Space Exploration Missions

机译：飞行过程中的免疫系统失调：深空探测任务的潜在对策

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recent studies have established that dysregulation of the human immune system and the reactivation of latent herpesviruses persists for the duration of a 6-month orbital spaceflight. It appears certain aspects of adaptive immunity are dysregulated during flight, yet some aspects of innate immunity are heightened. Interaction between adaptive and innate immunity also seems to be altered. Some crews experience persistent hypersensitivity reactions during flight. This phenomenon may, in synergy with extended duration and galactic radiation exposure, increase specific crew clinical risks during deep space exploration missions. The clinical challenge is based upon both the frequency of these phenomena in multiple crewmembers during low earth orbit missions and the inability to predict which specific individual crewmembers will experience these changes. Thus, a general countermeasure approach that offers the broadest possible coverage is needed. The vehicles, architecture, and mission profiles to enable such voyages are now under development. These include deployment and use of a cis-Lunar station (mid 2020s) with possible Moon surface operations, to be followed by multiple Mars flyby missions, and eventual human Mars surface exploration. Current ISS studies will continue to characterize physiological dysregulation associated with prolonged orbital spaceflight. However, sufficient information exists to begin consideration of both the need for, and nature of, specific immune countermeasures to ensure astronaut health. This article will review relevant in-place operational countermeasures onboard ISS and discuss a myriad of potential immune countermeasures for exploration missions. Discussion points include nutritional supplementation and functional foods, exercise and immunity, pharmacological options, the relationship between bone and immune countermeasures, and vaccination to mitigate herpes (and possibly other) virus risks. As the immune system has sentinel connectivity within every other physiological system, translational effects must be considered for all potential immune countermeasures. Finally, we shall discuss immune countermeasures in the context of their individualized implementation or precision medicine, based on crewmember specific immunological biases.
机译：最近的研究已经确定，人体免疫系统失调和潜伏性疱疹病毒的重新激活在6个月的轨道航天飞行期间持续存在。似乎在飞行过程中自适应免疫的某些方面失调，但先天免疫的某些方面却增强了。适应性免疫和先天性免疫之间的相互作用似乎也被改变。一些机组人员在飞行过程中会遇到持续的超敏反应。这种现象可能与持续时间延长和银河辐射暴露协同作用，增加了在深空探索任务中特定机组人员的临床风险。临床挑战既基于低空轨道飞行任务中多个机组成员中这些现象的发生频率，又基于无法预测哪些特定机组成员将经历这些变化。因此，需要提供尽可能广泛的覆盖范围的通用对策方法。现在正在开发能够进行此类航行的车辆，架构和任务配置文件。其中包括部署和使用可能在月球表面运行的顺月站（2020年代中期），随后进行多次火星飞行任务，以及最终的人类火星表面探索。当前的国际空间站研究将继续表征与长时间轨道飞行有关的生理失调。但是，有足够的信息来开始考虑确保宇航员健康的特定免疫对策的必要性和性质。本文将回顾国际空间站上的相关就地操作对策，并讨论探索任务的无数潜在免疫对策。讨论重点包括营养补充和功能食品，运动和免疫力，药理选择，骨骼与免疫对策之间的关系以及减轻疱疹（可能还有其他）病毒风险的疫苗接种。由于免疫系统在所有其他生理系统中都有前哨连接，因此对于所有潜在的免疫对策都必须考虑翻译作用。最后，我们将根据机组人员的具体免疫偏倚，在个体化实施或精密医学的背景下讨论免疫对策。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号