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WHO/IUIS Allergen Nomenclature: Providing a common language

机译:世卫组织/ IUIS过敏原命名法:提供一种通用语言

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摘要

A systematic nomenclature for allergens originated in the early 1980s, when few protein allergens had been described. A group of scientists led by Dr. David G. Marsh developed a nomenclature based on the Linnaean taxonomy, and further established the World Health Organization/International Union of Immunological Societies (WHO/IUIS) Allergen Nomenclature Sub-Committee in 1986. Its stated aim was to standardize the names given to the antigens (allergens) that caused IgE-mediated allergies in humans. The Sub-Committee first published a revised list of allergen names in 1986, which continued to grow with rare publications until 1994. Between 1994 and 2007 the database was a text table online, then converted to a more readily updated website. The allergen list became the Allergen Nomenclature database (), which currently includes approximately 880 proteins from a wide variety of sources. The Sub-Committee includes experts on clinical and molecular allergology. They review submissions of allergen candidates, using evidence-based criteria developed by the Sub-Committee. The review process assesses the biochemical analysis and the proof of allergenicity submitted, and aims to assign allergen names prior to publication. The Sub-Committee maintains and revises the database, and addresses continuous challenges as new “omics” technologies provide increasing data about potential new allergens. Most journals publishing information on new allergens require an official allergen name, which involves submission of confidential data to the WHO/IUIS Allergen Nomenclature Sub-Committee, sufficient to demonstrate binding of IgE from allergic subjects to the purified protein.
机译:过敏原的系统命名法起源于1980年代初期,当时很少描述蛋白质过敏原。由David G. Marsh博士领导的一组科学家基于Linnaean分类法制定了一个术语,并于1986年进一步建立了世界卫生组织/国际免疫学会联合会变应原命名法分委员会。其既定目标旨在标准化引起人类IgE介导的过敏原的抗原(过敏原)的名称。小组委员会于1986年首次发布了修订的过敏原名称列表,直到1994年,该列表一直以稀有出版物的形式增长。1994年至2007年间,该数据库是在线文本表,然后转换为更易于更新的网站。过敏原列表成为过敏原命名数据库(),目前包含来自多种来源的大约880种蛋白质。该小组委员会包括临床和分子过敏学专家。他们使用小组委员会制定的基于证据的标准来审查过敏原候选物的提交。审查过程评估生化分析和提交的致敏性证明,旨在在出版前指定过敏原名称。该小组委员会负责维护和修改数据库,并应对不断的挑战,因为新的“组学”技术可提供有关潜在新过敏原的越来越多的数据。大多数发表有关新变应原信息的期刊都要求使用正式的变应原名称,该名称涉及向WHO / IUIS变应原命名分委员会提交机密数据,足以证明变应原受试者的IgE与纯化蛋白的结合。

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