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14-3-3 Proteins in Plant Hormone Signaling: Doing Several Things at Once

机译:植物激素信号传导中的14-3-3蛋白:一次做几件事

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摘要

In this review we highlight the advances achieved in the investigation of the role of 14-3-3 proteins in hormone signaling, biosynthesis, and transport. 14-3-3 proteins are a family of conserved molecules that target a number of protein clients through their ability to recognize well-defined phosphorylated motifs. As a result, they regulate several cellular processes, ranging from metabolism to transport, growth, development, and stress response. High-throughput proteomic data and two-hybrid screen demonstrate that 14-3-3 proteins physically interact with many protein clients involved in the biosynthesis or signaling pathways of the main plant hormones, while increasing functional evidence indicates that 14-3-3-target interactions play pivotal regulatory roles. These advances provide a framework of our understanding of plant hormone action, suggesting that 14-3-3 proteins act as hubs of a cellular web encompassing different signaling pathways, transducing and integrating diverse hormone signals in the regulation of physiological processes.
机译:在这篇综述中,我们重点介绍了在研究14-3-3蛋白在激素信号传导,生物合成和运输中的作用方面取得的进展。 14-3-3蛋白质是一类保守分子,它们通过识别明确定义的磷酸化基序的能力而靶向许多蛋白质客户。结果,它们调节从新陈代谢到转运,生长,发育和应激反应的几个细胞过程。高通量蛋白质组学数据和两杂交筛查表明14-3-3蛋白与许多参与主要植物激素生物合成或信号传导途径的蛋白客户发生物理相互作用,而功能证据的增加表明14-3-3-target相互作用起着关键的监管作用。这些进展提供了我们对植物激素作用的理解的框架,表明14-3-3蛋白充当细胞网的枢纽,涵盖不同的信号传导途径,在生理过程的调控中转导和整合各种激素信号。

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