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Monoamine Oxidase-A Inhibition and Associated Antioxidant Activity in Plant Extracts with Potential Antidepressant Actions

机译：具有潜在抗抑郁作用的植物提取物中的单胺氧化酶-A抑制作用和相关的抗氧化活性

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摘要

Monoamine oxidase (MAO) catalyzes the oxidative deamination of amines and neurotransmitters and is involved in mood disorders, depression, oxidative stress, and adverse pharmacological reactions. This work studies the inhibition of human MAO-A by Hypericum perforatum, Peganum harmala, and Lepidium meyenii, which are reported to improve and affect mood and mental conditions. Subsequently, the antioxidant activity associated with the inhibition of MAO is determined in plant extracts for the first time. H. perforatum inhibited human MAO-A, and extracts from flowers gave the highest inhibition (IC50 of 63.6 μg/mL). Plant extracts were analyzed by HPLC-DAD-MS and contained pseudohypericin, hypericin, hyperforin, adhyperforin, hyperfirin, and flavonoids. Hyperforin did not inhibit human MAO-A and hypericin was a poor inhibitor of this isoenzyme. Quercetin and flavonoids significantly contributed to MAO-A inhibition. P. harmala seed extracts highly inhibited MAO-A (IC50 of 49.9 μg/L), being a thousand times more potent than H. perforatum extracts owing to its content of β-carboline alkaloids (harmaline and harmine). L. meyenii root (maca) extracts did not inhibit MAO-A. These plants may exert protective actions related to antioxidant effects. Results in this work show that P. harmala and H. perforatum extracts exhibit antioxidant activity associated with the inhibition of MAO (i.e., lower production of H2O2).
机译：单胺氧化酶（MAO）催化胺和神经递质的氧化脱氨作用，并涉及情绪障碍，抑郁，氧化应激和不良药理反应。这项工作研究了贯叶连翘，骆驼蓬和延叶草对人MAO-A的抑制作用，据报道它们可以改善并影响情绪和精神状况。随后，首次确定了植物提取物中与抑制MAO有关的抗氧化活性。贯叶连翘抑制人MAO-A，花中提取物具有最高的抑制作用（IC50为63.6μg/ mL）。植物提取物通过HPLC-DAD-MS分析，并包含假高丝菌素，金丝桃素，金丝桃素，肾上腺素，金丝桃素和类黄酮。 Hyperforin不会抑制人的MAO-A，而hypericin则不能很好地抑制这种同工酶。槲皮素和类黄酮显着促成MAO-A抑制。 P. harmala种子提取物高度抑制MAO-A（IC50为49.9μg/ L），由于其β-咔啉生物碱（harmaline和harmine）的含量，其通气能力比穿孔木提取物强1000倍。 meyenii根（玛卡）提取物不抑制MAO-A。这些植物可能发挥与抗氧化作用有关的保护作用。这项工作的结果表明，骆驼提取物和贯叶连翘提取物表现出与抑制MAO有关的抗氧化活性（即，较低的H2O2产生）。

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    Tomás Herraiz; Hugo Guillén;

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  • 年(卷),期 -1(2018),-1
  • 年度 -1
  • 页码 4810394
  • 总页数 10
  • 原文格式 PDF
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