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Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits

机译：突触神经素复合物：神经回路逻辑的分子代码。

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Synapses are specialized junctions between neurons in brain that transmit and compute information, thereby connecting neurons into millions of overlapping and interdigitated neural circuits. Here we posit that the establishment, properties, and dynamics of synapses are governed by a molecular logic that is controlled by diverse trans-synaptic signaling molecules. Neurexins, expressed in thousands of alternatively spliced isoforms, are central components of this dynamic code. Presynaptic neurexins regulate synapse properties via differential binding to multifarious postsynaptic ligands, such as neuroligins, cerebellin/GluD complexes, and latrophilins, thereby shaping the input/output relations of their resident neural circuits. Mutations in genes encoding neurexins and their ligands are associated with diverse neuropsychiatric disorders, especially schizophrenia, autism, and Tourette syndrome. Thus, neurexins nucleate an overall trans-synaptic signaling network that controls synapse properties, that thereby determines the precise responses of synapses to spike patterns in a neuron and circuit, and that is vulnerable to impairments in neuropsychiatric disorders.

机译：突触是大脑中神经元之间的专用连接，可以传输和计算信息，从而将神经元连接到数百万个重叠且相互交叉的神经回路中。在这里，我们假设突触的建立，性质和动力学受分子逻辑控制，该分子逻辑由不同的跨突触信号分子控制。在成千上万的可变剪接同工型中表达的神经毒素是该动态密码的核心组成部分。突触前神经毒素通过与多种突触后配体（例如神经胶蛋白，小脑/ GluD复合物和亲脂蛋白）的差异结合来调节突触特性，从而改变其驻留神经回路的输入/输出关系。编码神经毒素及其配体的基因突变与多种神经精神疾病有关，尤其是精神分裂症，自闭症和图雷特综合症。因此，神经毒素使控制突触特性的整个跨突触信号传递网络成核，从而确定突触对神经元和回路中突波模式的精确响应，并且容易受到神经精神疾病障碍的影响。

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期刊名称 other
作者
Thomas C. Südhof;
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年(卷),期 -1(171),4
年度 -1
页码 745–769
总页数 46
原文格式 PDF
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专利

1. Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits [J] . Sudhof Thomas C. Cell . 2017,第4期

机译：突触Neurexin复合物：神经电路逻辑的分子代码
2. Endocannabinoid Mediates Excitatory Synaptic Function of β-Neurexins. Commentary: β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling [J] . Hansen Wang Frontiers in Neuroscience . 2016,第2016期

机译：内源性大麻素介导β-神经毒素的兴奋性突触功能。评论：β-神经毒素通过调节突触内源性大麻素信号传导来控制神经回路。
3. Logic circuits of variable function using neural networks and their method of calculating synaptic weights [J] . Masahiro Teramura, Teruaki Nomiyama, Tomoyuki Miyazaki Electronics and communications in Japan. Part 3 . 2000,第1期

机译：使用神经网络的可变函数逻辑电路及其突触权重的计算方法
4. Memristive Synaptic Circuits for Deep Convolutional Neural Networks [C] . Menglin Cui, Yang Zhang IEEE International Symposium on Circuits and Systems . 2019

机译：深度卷积神经网络的忆阻突触电路
5. The Neural Circuits and Synaptic Mechanism Underlying Motor Initiation in Caenorhabditis elegans. [D] . Piggott, Beverly J. 2012

机译：秀丽隐杆线虫的神经回路和突触机制背后的运动开始。
6. Endocannabinoid Mediates Excitatory Synaptic Function of β-Neurexins. Commentary: β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling [O] . Hansen Wang 2016

机译：内源性大麻素介导β-神经毒素的兴奋性突触功能。评论：β-神经毒素通过调节突触内源性大麻素信号控制神经回路。
7. Endocannabinoid Mediates Excitatory Synaptic Function of β-Neurexins. Commentary: β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling [O] . Hansen Wang 2016

机译：内源性大麻素介导β-内皮素的兴奋性突触功能。评论：β-Neurexins通过调节突触内源性大麻素信号控制神经回路

Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits

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