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首页> 美国卫生研究院文献>Frontiers in Physiology >Xiao-Yao-San a Chinese Medicine Formula Ameliorates Chronic Unpredictable Mild Stress Induced Polycystic Ovary in Rat
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Xiao-Yao-San a Chinese Medicine Formula Ameliorates Chronic Unpredictable Mild Stress Induced Polycystic Ovary in Rat

机译：逍遥散一种中药配方改善了大鼠慢性不可预测的轻度应激诱导的多囊卵巢

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Chronic stress induces endocrine disturbance, which contributes to the development of polycystic ovary syndrome (PCOS), a condition that remains a challenge for clinicians to cope with. The present study investigated the effect of Xiao-Yao-San (XYS), a traditional Chinese medicine formula used for treatment of gynecological disease, on the chronic stress-induced polycystic ovary and its underlying mechanism. Female Sprague-Dwaley rats underwent a 3 weeks chronic unpredictable mild stress (CUMS) procedure to establish the PCOS model, followed by 4 weeks treatment with XYS (0.505 g/kg or 1.01 g/kg) by gavage. Granulosa cells were exposed to noradrenaline (1 mM) in vitro for 24 h, followed by incubation with or without XYS-treated rat serum for 24 h. Post-treatment with XYS ameliorated CUMS-induced irregular estrous cycles and follicles development abnormalities, decrease of estradiol and progesterone level as well as increase of luteinizing hormone in serum, reduced cystic follicles formation and the apoptosis and autophagy of granulosa cells, attenuated the increase in dopamine beta hydroxylase and c-fos level in locus coeruleus, the noradrenaline level in serum and ovarian tissue, and the expression of beta 2 adrenergic receptor in ovarian tissue. Besides, XYS alleviated the reduction of phosphorylation of ribosomal protein S6 kinase polypeptide I and protein kinase B, as well as the increase of microtubule-associated protein light chain 3-I to microtubule-associated protein light chain 3-II conversion both in vivo and in vitro. This study demonstrated XYS as a potential strategy for CUMS induced polycystic ovary, and suggested that the beneficial role of XYS was correlated with the regulation of the sympathetic nerve activity.
机译：慢性应激会诱发内分泌紊乱，从而导致多囊卵巢综合症（PCOS）的发展，而多囊卵巢综合症仍然是临床医生要应对的挑战。本研究调查了用于治疗妇科疾病的中药配方药逍遥散（XYS）对慢性应激诱导的多囊卵巢的影响及其潜在机制。对雌性Sprague-Dwaley大鼠进行3周的慢性不可预测的轻度应激（CUMS）程序以建立PCOS模型，然后通过强饲法用XYS（0.505 g / kg或1.01 g / kg）处理4周。将颗粒细胞体外暴露于去甲肾上腺素（1 mM）24小时，然后在有或没有XYS处理的大鼠血清中温育24小时。 XYS的后处理改善了CUMS诱导的不规则发情周期和卵泡发育异常，雌二醇和孕酮水平降低以及血清中黄体生成素的增加，囊性卵泡的形成减少以及颗粒细胞的凋亡和自噬，从而减弱了颗粒的增加。蓝斑中多巴胺β羟化酶和c-fos水平，血清和卵巢组织中去甲肾上腺素水平以及卵巢组织中β2肾上腺素受体的表达。此外，XYS减轻了体内和体外核糖体蛋白S6激酶多肽I和蛋白激酶B磷酸化的减少，以及微管相关蛋白轻链3-I向微管相关蛋白轻链3-II转化的增加。体外。这项研究表明XYS作为CUMS诱导多囊卵巢的一种潜在策略，并表明XYS的有益作用与交感神经活动的调节相关。

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