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On the analysis of complex biological supply chains: From Process Systems Engineering to Quantitative Systems Pharmacology

机译：关于复杂生物供应链的分析：从过程系统工程到定量系统药理学

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The use of models in biology has become particularly relevant as it enables investigators to develop a mechanistic framework for understanding the operating principles of living systems as well as in quantitatively predicting their response to both pathological perturbations and pharmacological interventions. This application has resulted in a synergistic convergence of systems biology and pharmacokinetic-pharmacodynamic modeling techniques that has led to the emergence of quantitative systems pharmacology (QSP). In this review, we discuss how the foundational principles of chemical process systems engineering inform the progressive development of more physiologically-based systems biology models.

机译：在生物学中使用模型已变得尤为重要，因为它使研究人员能够建立一个机制框架，以理解生命系统的工作原理，并定量预测其对病理性扰动和药物干预的反应。此应用程序导致系统生物学和药代动力学-药效学建模技术的协同融合，从而导致了定量系统药理学（QSP）的出现。在这篇综述中，我们讨论了化学过程系统工程的基本原理如何指导更多基于生理的系统生物学模型的逐步发展。

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期刊名称 other
作者
Rohit T. Rao; Megerle L. Scherholz; Clara Hartmanshenn; Seul-A Bae; Ioannis P. Androulakis;
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作者单位

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年(卷),期 -1(107),-1
年度 -1
页码 100–110
总页数 26
原文格式 PDF
正文语种
中图分类
关键词
Pharmacokinetics pharmacodynamics multi-scale systems biology quantitative systems pharmacology;

机译：药代动力学;药效学;多尺度系统生物学;定量系统药理学;

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专利

1. On the analysis of complex biological supply chains: From process systems engineering to quantitative systems pharmacology [J] . Rohit T. Rao, Megerle L Scherholz, Clara Hartmanshenn, Computers & Chemical Engineering . 2017,第deca5期

机译：关于复杂生物供应链的分析：从过程系统工程到定量系统药理学
2. A Survey of Model-Based System Engineering Methods to Analyse Complex Supply Chains: A Case Study in Semiconductor Supply Chain [J] . Behrouz Alizadeh Mousavi, Radhia Azzouz, Cathal Heavey, IFAC PapersOnLine . 2019,第13期

机译：基于模型的系统工程分析复杂供应链的方法研究：以半导体供应链为例
3. The second face of systems integration: An empirical analysis of supply chains to complex product systems [J] . Gholz Eugene, James Andrew D., Speller Thomas H. Research policy . 2018,第8期

机译：系统集成的第二面：对复杂产品系统的供应链的实证分析
4. A Survey of Model-Based System Engineering Methods to Analyse Complex Supply Chains: A Case Study in Semiconductor Supply Chain [C] . Behrouz Alizadeh Mousavi, Radhia Azzouz, Cathal Heavey, IFAC Conference on Manufacturing Modelling, Management, and Control . 2020

机译：基于模型的系统工程方法调查分析复杂供应链：半导体供应链的案例研究
5. Statics and dynamics of complex network systems: Supply chain analysis and financial networks with intermediation. [D] . Ke, Ke. 2004

机译：复杂网络系统的静态和动态：具有中介的供应链分析和金融网络。
6. Systems analysis reveals complex biological processes during virus infection fate decisions [O] . Jordi Argilaguet, Mireia Pedragosa, Anna Esteve-Codina, 2019

机译：系统分析揭示了病毒感染命运决定过程中的复杂生物过程
7. On the analysis of complex biological supply chains: From process systems engineering to quantitative systems pharmacology [O] . Rohit T. Rao, Megerle L. Scherholz, Clara Hartmanshenn, 2017

机译：复杂生物供应链分析：从过程系统工程到定量系统药理学

On the analysis of complex biological supply chains: From Process Systems Engineering to Quantitative Systems Pharmacology

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