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首页> 美国卫生研究院文献>other >Structural and functional changes in the microcirculation of lepromatous leprosy patients - Observation using orthogonal polarization spectral imaging and laser Doppler flowmetry iontophoresis
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Structural and functional changes in the microcirculation of lepromatous leprosy patients - Observation using orthogonal polarization spectral imaging and laser Doppler flowmetry iontophoresis

机译：麻风病麻风患者微循环的结构和功能变化-用正交偏振光谱成像和激光多普勒血流离子渗透仪观察

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Leprosy is a chronic granulomatous infection of skin and peripheral nerves caused by Mycobacterium leprae and is considered the main infectious cause of disability worldwide. Despite the several studies regarding leprosy, little is known about its effects on microvascular structure and function in vivo. Thus, we have aimed to compare skin capillary structure and functional density, cutaneous vasomotion (spontaneous oscillations of arteriolar diameter), which ensures optimal blood flow distribution to skin capillaries) and cutaneous microvascular blood flow and reactivity between ten men with lepromatous leprosy (without any other comorbidity) and ten age- and gender-matched healthy controls. Orthogonal polarization spectral imaging was used to evaluate skin capillary morphology and functional density and laser Doppler flowmetry to evaluate blood flow, vasomotion and spectral analysis of flowmotion (oscillations of blood flow generated by vasomotion) and microvascular reactivity, in response to iontophoresis of acetylcholine and sodium nitroprusside. The contribution of different frequency components of flowmotion (endothelial, neurogenic, myogenic, respiratory and cardiac) was not statistically different between groups. However, endothelial-dependent and -independent vasodilatations elicited by acetylcholine and sodium nitroprusside iontophoresis, respectively, were significantly reduced in lepromatous leprosy patients compared to controls, characterizing the existence of microvascular dysfunction. These patients also presented a significant increase in the number of capillaries with morphological abnormalities and in the diameters of the dermal papilla and capillary bulk when compared to controls. Our results suggest that lepromatous leprosy causes severe microvascular dysfunction and significant alterations in capillary structure. These structural and functional changes are probably induced by exposure of the microvascular bed to chronic inflammation evoked by the Mycobacterium leprae.
机译：麻风病是由麻风分枝杆菌引起的皮肤和周围神经的慢性肉芽肿性感染，被认为是全世界致残的主要感染原因。尽管对麻风病进行了数项研究，但对其在体内对微血管结构和功能的影响知之甚少。因此，我们的目标是比较十名麻风病麻风病患者（无任何人）的皮肤毛细血管结构和功能密度，皮肤血管运动（自发振荡的小动脉直径，可确保向皮肤毛细血管的最佳血流分布）和皮肤微血管血流和反应性。其他合并症）和十个年龄和性别相匹配的健康对照。正交极化光谱成像用于评估皮肤毛细血管形态和功能密度，激光多普勒血流仪用于评估血流，血管运动以及血流运动（由血管运动产生的血流振荡）和微血管反应性的频谱分析，以响应乙酰胆碱和钠的离子电渗疗法硝普钠。两组之间不同频率的血流运动（内皮，神经源性，肌源性，呼吸和心脏）的贡献在统计学上没有差异。然而，与对照相比，麻风麻风病人的乙酰胆碱和硝普钠钠离子电渗疗法分别引起的内皮依赖性和非依赖性血管舒张明显减少，这说明存在微血管功能障碍。与对照组相比，这些患者的形态异常毛细血管数目以及真皮乳头和毛细血管的直径也显着增加。我们的结果表明，麻风病的麻风病会导致严重的微血管功能障碍和毛细血管结构的重大改变。这些结构和功能的变化可能是由于微血管床暴露于麻风分枝杆菌引起的慢性炎症而引起的。

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