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Nonhuman primate model of polytraumatic hemorrhagic shock recapitulates early platelet dysfunction observed following severe injury in humans

机译：非人类灵长类动物多创伤性失血性休克模型概括了人类严重受伤后观察到的早期血小板功能障碍

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BACKGROUNDPlatelet dysfunction has been described as an early component of trauma-induced coagulopathy. The platelet component of trauma-induced coagulopathy remains to be fully elucidated and translatable animal models are required to facilitate mechanistic investigations. We sought to determine if the early platelet dysfunction described in trauma patients could be recapitulated in a nonhuman primate model of polytraumatic hemorrhagic shock.

机译：背景技术血小板功能障碍已被描述为创伤引起的凝血病的早期成分。创伤引起的凝血病的血小板成分仍有待充分阐明，需要可翻译的动物模型以促进机制研究。我们试图确定在创伤性患者中描述的早期血小板功能障碍是否可以在非人类灵长类动物多创伤性出血性休克模型中概括。

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期刊名称 other
作者
Leasha J. Schaub; Hunter B. Moore; Andrew P. Cap; Jacob J. Glaser; Ernest E. Moore; Forest R. Sheppard;
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年(卷),期 -1(82),3
年度 -1
页码 461–469
总页数 19
原文格式 PDF
正文语种
中图分类
关键词
Trauma hemorrhage platelets nonhuman primate;

机译：创伤;出血;血小板;非人类灵长类动物;

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专利

1. Control of severe intra-abdominal hemorrhage with an infusible platelet-derived hemostatic agent in a nonhuman primate (rhesus macaque) model [J] . Macko Antoni R., Crossland Randy F., Cap Andrew P., The journal of trauma and acute care surgery . 2016,第4期

机译：在非人灵长类动物（恒河猴）模型中用不溶性血小板衍生的止血剂控制严重的腹腔内出血
2. Tissue injury suppresses fibrinolysis after hemorrhagic shock in nonhuman primates (rhesus macaque) [J] . Antoni R. Macko, Hunter B. Moore, Andrew P. Cap, The journal of trauma and acute care surgery . 2017,第4期

机译：非人底灵长类动物（恒河猕猴）出血休克后抑制纤维蛋白损伤
3. Prehospital whole blood resuscitation prevents coagulopathy and improves acid–base status at hospital arrival in a nonhuman primate hemorrhagic shock model [J] . Sheppard Forest R., Mitchell Thomas A., Cap Andrew P., Transfusion: The Journal of the American Association of Blood Banks . 2019,第7期

机译：预孢子产量全血可防止凝结病变，改善医院到达的酸碱地位在非人犬灵长类动物出血震动模型中
4. Laser-induced retinal nerve fiber layer injury in the nonhuman primate [C] . Harry Zwick, Walter Reed Army Institute of Research, San Antonio, Laser-Inflicted Eye Injuries: Epidemiology, Prevention, and Treatment . 1996

机译：激光诱发非人类灵长类动物的视网膜神经纤维层损伤
5. Primate Skeletal Epigenetics: Evolutionary Implications of DNA Methylation Patterns in the Skeletal Tissues of Human and Nonhuman Primates [D] . Housman, Genevieve. 2017

机译：灵长类动物骨骼表观遗传学：DNA甲基化模式在人和非人类骨骼组织中的进化意义
6. Tissue injury suppresses fibrinolysis after hemorrhagic shock in nonhuman primates (rhesus macaque) [O] . Antoni R. Macko, Hunter B. Moore, Andrew P. Cap, -1

机译：非人灵长类动物（恒河猴）出血性休克后组织损伤抑制纤维蛋白溶解
7. Nonhuman primate model of polytraumatic hemorrhagic shock recapitulates early platelet dysfunction observed following severe injury in humans [O] . Leasha J. Schaub, Hunter B. Moore, Andrew P. Cap, 2017

机译：多人抑制性失血性休克的非人类灵长类动物模型概括了人类严重损伤后观察到的早期血小板功能障碍

Nonhuman primate model of polytraumatic hemorrhagic shock recapitulates early platelet dysfunction observed following severe injury in humans

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