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Arginine methylation dysfunction increased risk of acute coronary syndrome in coronary artery disease population

机译：精氨酸甲基化功能障碍增加了冠心病人群中急性冠脉综合征的风险

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The plasma levels of asymmetric dimethylarginine (ADMA) had been proved to be an independent cardiovascular risk factor. Few studies involved the entire arginine methylation dysfunction. This study was designed to investigate whether arginine methylation dysfunction is associated with acute coronary syndrome risk in coronary artery disease population.In total 298 patients undergoing coronary angiography because of chest pain with the diagnosis of stable angina pectoris or acute coronary syndrome from February 2013 to June 2014 were included. Plasma levels of free arginine, citrulline, ornithine, and the methylated form of arginine, ADMA, and symmetric dimethylarginine (SDMA) were measured with high-performance liquid chromatography coupled with tandem mass spectrometry. We examined the relationship between arginine metabolism-related amino acids or arginine methylation index (AMI, defined as ratio of [arginine + citrulline + ornithine]/[ADMA + SDMA]) and acute coronary events.We found that plasma ADMA levels were similar in the stable angina pectoris group and the acute coronary syndrome group (P = 0.88); the AMI differed significantly between 2 groups (P < 0.001). Multivariate logistic regression demonstrated that AMI was an independent risk factor of acute coronary events in patients with coronary artery disease (OR = 0.975, 95% confidence interval 0.956–0.993; P = 0.008).Our study suggested that ADMA levels were very similar in the stable angina and acute coronary syndrome patients; AMI might be an independent risk factor of acute coronary events in coronary artery disease population.
机译：血浆不对称二甲基精氨酸（ADMA）的水平已被证明是独立的心血管危险因素。很少有研究涉及整个精氨酸甲基化功能障碍。本研究旨在调查精氨酸甲基化功能障碍是否与冠心病人群中的急性冠状动脉综合征风险相关.2013年2月至2013年6月，共298例因胸痛而进行了冠脉造影的患者被诊断为稳定型心绞痛或急性冠脉综合征2014年包括在内。用高效液相色谱-串联质谱法测定血浆中的游离精氨酸，瓜氨酸，鸟氨酸以及甲基化形式的精氨酸，ADMA和对称二甲基精氨酸（SDMA）的水平。我们检查了精氨酸代谢相关氨基酸或精氨酸甲基化指数（AMI，定义为[精氨酸+ in瓜氨酸+鸟氨酸] / [ADMA + SDMA]的比率）与急性冠脉事件之间的关系。我们发现血浆中的ADMA水平相似稳定型心绞痛组和急性冠脉综合征组（P = 0.88）；两组之间的AMI有显着差异（P <0.001）。多因素logistic回归分析表明，AMI是冠心病患者急性冠脉事件的独立危险因素（OR = 0.975，95％置信区间0.956-0.993； P = 0.008）。我们的研究表明，ADMA水平在冠心病中非常相似。稳定型心绞痛和急性冠脉综合征患者； AMI可能是冠状动脉疾病人群中急性冠脉事件的独立危险因素。

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