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首页> 美国卫生研究院文献>other >IL-10-Producing CD1dhiCD5+ Regulatory B Cells May Play a Critical Role in Modulating Immune Homeostasis in Silicosis Patients
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IL-10-Producing CD1dhiCD5+ Regulatory B Cells May Play a Critical Role in Modulating Immune Homeostasis in Silicosis Patients

机译：产生IL-10-的CD1dhiCD5 +调节性B细胞在调节矽肺患者的免疫稳态中可能起关键作用

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Silicosis is characterized by chronic lung inflammation and fibrosis, which are extremely harmful to human health. The pathogenesis of silicosis involves uncontrolled immune processes. Evidence supports that regulatory B cells (Bregs) produce negative regulatory cytokines, such as IL-10, which can negatively regulate immune responses in inflammation and autoimmune diseases. Our previous study found that IL-10-producing B cells were involved in the development of silica-induced lung inflammation and fibrosis of mice. However, little is known about the role of Bregs in silicosis patients (SP). In this study, we found that serum concentrations of IL-10 were significantly increased in SP by using protein array screening. We further determined that the frequency of IL-10-producing CD1dhiCD5+ Bregs, not IL-10-producing non-B lymphocytes, was significantly higher in SP compared to subjects under surveillance (SS) and healthy workers (HW) by flow cytometry. We also found that regulatory T cells (Tregs) and Th2 cytokines (IL-4, IL-5, and IL-13) were significantly increased in SP. Th1 cytokines (IFN-γ, IL-2, and IL-12) and inflammatory cytokines (IL-1β, IL-6, and TNF-α) were not significantly different between SP, SS, and HW. Our study indicated that IL-10-producing CD1dhiCD5+ Bregs might maintain Tregs and regulate Th1/Th2 polarization in SP, suggesting that IL-10-producing Bregs may play a critical role in modulating immune homeostasis in SP.
机译：矽肺病的特征是慢性肺部炎症和纤维化，对人体健康极为有害。矽肺病的发病机制涉及不受控制的免疫过程。有证据支持调节性B细胞（Bregs）产生负性调节性细胞因子，例如IL-10，可以消极调节炎症和自身免疫性疾病中的免疫反应。我们先前的研究发现，产生IL-10的B细胞参与了二氧化硅诱导的小鼠肺部炎症和纤维化的发展。但是，关于Bregs在矽肺病（SP）中的作用了解甚少。在这项研究中，我们发现通过使用蛋白质阵列筛选，SP中的IL-10血清浓度显着增加。我们进一步确定，与不产生IL-10的非B淋巴细胞相比，产生IL-10-的CD1d hi CD5 + Bregs的频率在SP中明显高于流式细胞仪检测受监视的受试者（SS）和健康工作者（HW）。我们还发现，调节性T细胞（Tregs）和Th2细胞因子（IL-4，IL-5和IL-13）在SP中显着增加。 SP，SS和HW之间的Th1细胞因子（IFN-γ，IL-2和IL-12）和炎性细胞因子（IL-1β，IL-6和TNF-α）没有显着差异。我们的研究表明，产生IL-10的CD1d hi CD5 + Bregs可以维持SP中的Tregs并调节Th1 / Th2极化，表明产生IL-10的Bregs可能发挥作用在调节SP的免疫稳态中起关键作用。

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