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Biochemistry in Endeavor Adventure Racers Study (BEARS)

机译:奋进冒险赛车研究(BEARS)中的生物化学

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摘要

Background: Adventure sports events consist of a combination of two or more endurance disciplines, such as orienteering, running, and rock climbing, that range from a day’s to a week’s duration. No studies have examined acute kidney injury (AKI) in adventure sports athletes.Objectives: To describe the prevalence of AKI in participants in the Endeavor Team Challenge, a 30-hour, 40-mile adventure race.Methods: In this prospective observational study, body weights were recorded at race registration. At the finish line, blood sample results by point-of-care testing and weights were recorded. Changes in serum creatinine (Cr) from an estimated baseline value and severity of AKI were calculated, with “risk of injury” defined as 1.5 x baseline Cr, and “injury” defined as 2 x baseline Cr. These two categories of AKI were combined to calculate the total prevalence. Results: There were 88 enrolled study participants with complete data available on 46 (52%). The mean age of those enrolled in the study was 36.8 years (+/- 7.7), 90% were males, and body mass index (BMI) was 25.7 kg/m2 (+/- 2.4). Of the competitors who completed the study, 34 (73%) had some degree of AKI, with 27 (58%) found to be at "risk" and seven (15%) with "injury". There was a significant correlation between weight loss and elevated Cr (r = -0.29, p = 0.047), with a trend towards nonsteroidal anti-inflammatory drug (NSAID) use being correlated with AKI (p = 0.058).Conclusion: Acute kidney injury was observed in the majority of the Endeavor Team Challenge adventure racers, similar to what has been observed in multistage ultramarathons, and greater than after standard marathons and single-stage ultramarathons.
机译:背景:冒险运动项目由定向训练,跑步和攀岩等两个或两个以上耐力运动项目组成,时间从一天到一周不等。没有研究检查冒险运动运动员的急性肾损伤(AKI)。目的:描述AKI在30小时,40英里冒险比赛Endeavor Team Challenge参与者中的患病率。方法:在这项前瞻性观察性研究中,在比赛登记时记录体重。在终点线上,记录了即时检验测试所得的血样结果和重量。计算了血清肌酐(Cr)与AKI的估计基线值和严重程度之间的变化,其中“受伤风险”定义为1.5 x基线Cr,“伤害”定义为2 x基线Cr。将这两个类别的AKI组合起来以计算总患病率。结果:有88名已登记的研究参与者,其中46名(52%)的完整数据可用。该研究的平均年龄为36.8岁(+/- 7.7),男性为90%,体重指数(BMI)为25.7 kg / m 2 (+/- 2.4) 。完成研究的竞争者中,有34(73%)人具有一定程度的AKI,其中27(58%)人处于“风险”,而7人(15%)为“伤害”。体重减轻与Cr升高之间存在显着相关性(r = -0.29,p = 0.047),非甾体抗炎药(NSAID)的使用趋势与AKI相关(p = 0.058)。结论:急性肾损伤在大多数“奋进队挑战赛”冒险赛车中都观察到这种现象,这与多级超级马拉松比赛中观察到的情况相似,并且比标准马拉松和单级超级马拉松比赛之后的情况要好。

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