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Candidate serum metabolite biomarkers for differentiating gastroesophageal reflux disease Barrett’s esophagus and high-grade dysplasia/esophageal adenocarcinoma

机译：候选血清代谢物生物标志物用于区分胃食管反流病巴雷特食管和高度不典型增生/食管腺癌

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Introduction/ObjectivesIncidence of esophageal adenocarcinoma (EA), an often fatal cancer, has increased sharply over recent decades. Several important risk factors (reflux, obesity, smoking) have been identified for EA and its precursor, Barrett’s esophagus (BE), but a key challenge remains identifying individuals at highest risk, since most with reflux do not develop BE, and most with BE do not progress to cancer. Metabolomics represents an emerging approach for identifying novel biomarkers associated with cancer development.

机译：简介/目的食管腺癌（EA）是一种经常致命的癌症，近几十年来急剧上升。对于EA及其前体Barrett食道（BE），已经确定了几个重要的危险因素（反流，肥胖，吸烟），但是识别高危人群仍然是一项关键挑战，因为大多数患有反流的人不会发展BE，而大多数患有BE。不发展为癌症。代谢组学是一种鉴定与癌症发展相关的新型生物标志物的新兴方法。

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期刊名称 other
作者
Matthew F. Buas; Haiwei Gu; Danijel Djukovic; Jiangjiang Zhu; Lynn Onstad; Brian J. Reid; Daniel Raftery; Thomas L. Vaughan;
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作者单位

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年(卷),期 -1(13),3
年度 -1
页码 23
总页数 18
原文格式 PDF
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中图分类
关键词
Barrett’s esophagus esophageal adenocarcinoma gastroesophageal reflux disease metabolomics serum biomarkers risk stratification;

机译：巴雷特食管;食道腺癌;胃食管反流病;代谢组学;血清生物标志物;风险分层;

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专利

1. Screening for esophageal adenocarcinoma and precancerous conditions (dysplasia and Barrett’s esophagus) in patients with chronic gastroesophageal reflux disease with or without other risk factors: two systematic reviews and one overview of reviews to inform a guideline of the Canadian Task Force on Preventive Health Care (CTFPHC) [J] . Candyce Hamel, Nadera Ahmadzai, Andrew Beck, Systematic Reviews . 2020,第1期

机译：患有或没有其他风险因素的慢性胃脂反流疾病患者的食管腺癌和癌前病症（发育不良和Barrett的食道）：两个系统评价和一个审查概述，以通知加拿大工作队对预防医疗保健的指导（CTFPHC ）
2. Screening for esophageal adenocarcinoma and precancerous conditions (dysplasia and Barrett's esophagus) in patients with chronic gastroesophageal reflux disease with or without other risk factors: two systematic reviews and one overview of reviews to inform a guideline of the Canadian Task Force on Preventive Health Care (CTFPHC) [J] . Progress in Artificial Intelligence . 2020,第1期

机译：患有或没有其他风险因素的慢性胃脂反流疾病患者食管腺癌和癌前病症（发育不良和Barrett的食管）：两个系统审查和审查概述，以告知加拿大工作队对预防医疗保健的指导意见（CTFPHC 的）
3. Differences in the definitions used for esophageal and gastric diseases in different countries: endoscopic definition of the esophagogastric junction, the precursor of Barrett's adenocarcinoma, the definition of Barrett's esophagus, and histologic criteria for mucosal adenocarcinoma or high-grade dysplasia. [J] . Takubo K, Vieth M, Aida Digestion . 2009,第4期

机译：各国在食道和胃疾病定义上的差异：内窥镜下食管胃交界处的定义，巴雷特氏腺癌的前体，巴雷特氏食管的定义以及粘膜腺癌或高度不典型增生的组织学标准。
4. Defining esophageal landmarks, gastroesophageal reflux disease, and Barrett's esophagus [C] . Kenneth DeVault, Barry P. McMahon, Altay Celebi, World Organization for Specialized Studies on Diseases of the Esophagus. . 2013

机译：定义食管地标，胃食管反流疾病和巴雷特的食道
5. Confocal laser endomicroscopy for Barrett's esophagus and gastroesophageal reflux disease. [D] . Dunbar, Kerry Brandt. 2012

机译：共聚焦激光内窥镜检查巴雷特食管和胃食管反流病。
6. Screening for esophageal adenocarcinoma and precancerous conditions (dysplasia and Barrett’s esophagus) in patients with chronic gastroesophageal reflux disease with or without other risk factors: two systematic reviews and one overview of reviews to inform a guideline of the Canadian Task Force on Preventive Health Care (CTFPHC) [O] . Candyce Hamel, Nadera Ahmadzai, Andrew Beck, 2020

机译：在有或没有其他危险因素的慢性胃食管反流病患者中筛查食管腺癌和癌前状况（发育异常和巴雷特食管）：两项系统评价和一项综述概述以告知加拿大预防保健工作队（CTFPHC）的指南）
7. Gastroesophageal reflux disease, Barrett esophagus, and esophageal adenocarcinoma – where do we stand? [O] . Ivana Mikolašević, Tomislav Bokun, Tajana Filipec Kanižaj 2018

机译：胃食管反流疾病，巴雷特食管和食管腺癌 - 我们站在哪里？
8. Gastroesophageal Reflux (GER) and Gastroesophageal Reflux Disease (GERD) in Adults. [R] . 2014

机译：成人胃食管反流（GER）和胃食管反流病（GERD）。

Candidate serum metabolite biomarkers for differentiating gastroesophageal reflux disease Barrett’s esophagus and high-grade dysplasia/esophageal adenocarcinoma

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