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Effects of propofol and sevoflurane on perioperative immune response in patients undergoing laparoscopic radical hysterectomy for cervical cancer

机译：丙泊酚和七氟醚对宫颈癌腹腔镜子宫全切术患者围手术期免疫反应的影响

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The aim of this study is to compare the effects of propofol and sevoflurane anesthesia on perioperative immune response in patients undergoing laparoscopic radical hysterectomy for cervical cancer.Sixty patients with cervical cancer scheduled for elective laparoscopic radical hysterectomy under general anesthesia were randomized into 2 groups. TIVA group received propofol induction and maintenance and SEVO group received sevoflurane induction and maintenance. Blood samples were collected at 30 min before induction (T0); the end of the operation (T1); and 24 h (T2), 48 h (T3), and 72 h (T4) after operation. The T lymphocyte subsets (including CD3+ cells, CD4+ cells, and CD8+ cells) and CD4+/CD8+ ratio, natural killer (NK) cells, and B lymphocytes were analyzed by flow cytometry.After surgery, all immunological indicators except CD8+ cells were significantly decreased in both groups compared to basal levels in T0, and the counts of CD3+ cells, CD4+ cells, NK cells, and the CD4+/CD8+ ratios were significantly lower in the SEVO groups than that in the TIVA group. However, the numbers of B cells were comparable at all the time points between 2 groups.Laparoscopic radical hysterectomy for cervical cancer is associated with postoperative lymphopenia. In terms of protecting circulating lymphocytes, propofol is superior to sevoflurane.
机译：本研究的目的是比较异丙酚和七氟醚麻醉对宫颈癌腹腔镜根治性子宫切除术患者围手术期免疫反应的影响。将60例计划在全身麻醉下进行选择性腹腔镜根治性子宫切除术的宫颈癌患者随机分为两组。 TIVA组接受异丙酚的诱导和维持，SEVO组接受七氟醚的诱导和维持。诱导前30分钟采集血样（T0）；操作结束（T1）；操作后分别为24？h（T2），48？h（T3）和72？h（T4）。流式细胞仪检测T淋巴细胞亚群（包括CD3 +细胞，CD4 +细胞和CD8 +细胞），CD4 + / CD8 +比值，自然杀伤（NK）细胞和B淋巴细胞，手术后除CD8 +细胞外所有免疫指标均明显降低与T0的基础水平相比，两组的SEVO组中CD3 +细胞，CD4 +细胞，NK细胞和CD4 + / CD8 +的数量均显着低于TIVA组。然而，两组之间在所有时间点的B细胞数量都是可比的。腹腔镜宫颈癌根治性子宫切除术与术后淋巴细胞减少有关。在保护循环淋巴细胞方面，丙泊酚优于七氟醚。

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