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High Resolution Ultrasound Superharmonic Perfusion Imaging: In Vivo Feasibility and Quantification of Dynamic Contrast-Enhanced Acoustic Angiography

机译：高分辨率超声超谐波灌注成像：体内可行性和定量的动态对比增强声血管造影。

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摘要

Mapping blood perfusion quantitatively allows localization of abnormal physiology and can improve understanding of disease progression. Dynamic contrast-enhanced ultrasound is a low-cost, real-time technique for imaging perfusion dynamics with microbubble contrast agents. Previously, we have demonstrated another contrast agent-specific ultrasound imaging technique, acoustic angiography, which forms static anatomical images of the superharmonic signal produced by microbubbles. In this work, we seek to determine whether acoustic angiography can be utilized for high resolution perfusion imaging in vivo by examining the effect of acquisition rate on superharmonic imaging at low flow rates and demonstrating the feasibility of dynamic contrast-enhanced superharmonic perfusion imaging for the first time. Results in the chorioallantoic membrane model indicate that frame rate and frame averaging do not affect the measured diameter of individual vessels observed, but that frame rate does influence the detection of vessels near and below the resolution limit. The highest number of resolvable vessels was observed at an intermediate frame rate of 3 Hz using a mechanically-steered prototype transducer. We also demonstrate the feasibility of quantitatively mapping perfusion rate in 2D in a mouse model with spatial resolution of ~100 µm. This type of imaging could provide non-invasive, high resolution quantification of microvascular function at penetration depths of several centimeters.
机译：定量映射血液灌注可以定位异常生理，并可以改善对疾病进展的了解。动态对比增强型超声是一种低成本的实时技术，用于使用微泡对比剂对灌注动力学进行成像。以前，我们已经展示了另一种造影剂特定的超声成像技术，即声学血管造影，该技术可形成由微气泡产生的超谐波信号的静态解剖图像。在这项工作中，我们试图通过在低流速下检查采集速率对超谐波成像的影响并证明动态对比度增强型超谐波灌注成像的可行性，来确定声血管造影是否可用于体内高分辨率灌注成像。时间。绒毛膜尿囊膜模型的结果表明，帧速率和帧平均不会影响所观察到的单个血管的测量直径，但是帧速率确实会影响分辨率极限附近和之下的血管的检测。使用机械转向的原型传感器，在3 Hz的中间帧频下观察到了最大数量的可分辨血管。我们还证明了在空间分辨率约为100 µm的小鼠模型中定量映射2D灌注率的可行性。这种类型的成像可以在几厘米的穿透深度处提供微血管功能的非侵入性高分辨率分辨率。

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