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Clinical risk assessment for gastric cancer in asymptomatic population after a health check-up

机译：健康检查后无症状人群胃癌的临床风险评估

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For the prevention of gastric cancer, the detection of risk factors associated with precancerous conditions may be more informative. The aim of this study was to identify the risk factors of gastric cancer, including precancerous conditions: atrophic gastritis (AG), intestinal metaplasia (IM), and dysplasia.The clinical and endoscopic findings of 60,261 adults who underwent gastroduodenoscopy as part of a health check-up were reviewed retrospectively. Subgroup analysis was conducted according to age, sex, cancer stage, and histology based on Lauren classification.Gastric cancer was diagnosed in 75 patients (0.12%). Both IM and AG were independent risk factors for gastric cancer in all subgroups. Male, older age, obesity, diabetes mellitus (DM), a salty and spicy diet, and Helicobacter pylori (H. pylori) were significantly associated with precancerous conditions. However, risk factors related to precancerous conditions were different according to age and sex. In <40 years, H. pylori was the only risk factor related to precancerous conditions, whereas DM with a salty and spicy diet were additional risk factors in ≥40 years. In female individuals, obesity was significant risk factor for precancerous conditions as well as H. pylori infection.AG and IM are independent risk factors for gastric cancer. To prevent gastric cancer, H. pylori eradication may be more useful in <40 years, whereas additional factors such as DM, obesity, salty and spicy diet may be important in female or ≥40 years.
机译：为了预防胃癌，与癌前状况相关的危险因素的检测可能会提供更多信息。这项研究的目的是确定胃癌的危险因素，包括癌前状况：萎缩性胃炎（AG），肠化生（IM）和发育异常.60,261名接受胃十二指肠镜检查作为健康的一部分的成年人的临床和内镜检查结果检查进行回顾性审查。根据年龄，性别，癌症分期和组织学根据Lauren分类进行亚组分析.75例患者被诊断出胃癌（0.12％）。 IM和AG都是所有亚组中胃癌的独立危险因素。男性，高龄，肥胖，糖尿病（DM），咸辣饮食和幽门螺杆菌（H. pylori）与癌前期状况显着相关。但是，根据年龄和性别，与癌前状况相关的危险因素有所不同。在不到40年的时间里，幽门螺杆菌是与癌前状态相关的唯一危险因素，而DM和盐渍和辛辣饮食是≥40年的其他危险因素。在女性个体中，肥胖是癌前疾病以及幽门螺杆菌感染的重要危险因素。AG和IM是胃癌的独立危险因素。为了预防胃癌，幽门螺杆菌的根除可能在<40年内更有用，而其他因素，例如DM，肥胖，咸和辛辣饮食在女性或40岁以上可能很重要。

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