• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>other >Correlates of infection and molecular characterization of blood-borne HIV HCV and HBV infections in HIV-1 infected inmates in Italy
【2h】

Correlates of infection and molecular characterization of blood-borne HIV HCV and HBV infections in HIV-1 infected inmates in Italy

机译：意大利感染HIV-1的囚犯中血液传播的HIVHCV和HBV感染的感染和分子特征的相关性

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Coinfection of blood-borne hepatitis B and hepatitis C viruses (HBV and HCV, respectively) in human immunodeficiency virus type 1 (HIV-1)-positive individuals frequently occurs in inmate population and peculiar viral strains and patterns of virological markers may be observed.Plasma from 69 HIV-1-positive inmates was obtained from 7 clinical centers connected with correctional centers in different towns in Italy. HIV, HBV, and HCV markers were tested by commercial assays. Virus genotyping was carried out by sequencing the protease and reverse transcriptase-encoding region (PR-RT region) for HIV and a region encompassing the NS5B gene for HCV and subsequent phylogenetic analysis.Twelve over 14 HIV-subtyped inmates were infected with HIV-1 subtype B strains. The 2 non-B strains belonged to subtype G and CRF02_AG, in an Italian and a Gambian patient, respectively. Variants carrying the K103N and Y181C resistance mutations to non-nucleoside reverse transcriptase inhibitors (NNRTIs) were found in 2 out of 9 patients naive for combined antiretroviral therapy (cART) (22.2%). Most HIV-positive patients (92.8%) showed evidence of past or present HBV and/or HCV infection. Prevalence of HBV and HCV was 81.2% for both viruses, whereas prevalence of HBV/HCV coinfection was 69.6%. A significantly higher presence of HCV infection was found in Italians [odds ratio (OR) 11.0; interval 1.7–80.9] and in drug users (OR 27.8; interval 4.9–186.0). HCV subtypes were determined in 42 HCV or HBV/HCV-coinfected individuals. HCV subtypes 1a, 3a, 4d, and 1b were found in 42.9%, 40.5%, 14.3%, and 2.4% of inmates, respectively. Low titers of HBV DNA in HBV DNA positive subjects precluded HBV subtyping.The high prevalence of HBV and HCV coinfections in HIV-infected inmates, as well as the heterogeneity of HIV and HCV subtypes suggest the need to adopt systematic controls in prisons to monitor both the burden and the genetic forms of blood-borne viral infections, in order to apply targeted therapeutic interventions.
机译：血液传播的乙型肝炎病毒和丙型肝炎病毒（分别为HBV和HCV）在人免疫缺陷病毒1型（HIV-1）阳性个体中的共感染经常发生在囚犯中，并且可以观察到独特的病毒株和病毒标记物的模式。从意大利不同城镇的7个临床中心（与惩教中心相关）获得了69名HIV-1阳性囚犯的血浆。 HIV，HBV和HCV标记通过商业化验进行测试。通过对HIV的蛋白酶和逆转录酶编码区（PR-RT区）以及一个包含HCV的NS5B基因的区进行测序并进行系统发育分析，对病毒进行基因分型。超过14个HIV亚型的囚犯感染了HIV-1 B亚型菌株。在意大利患者和冈比亚患者中，这两种非B菌株分别属于G和CRF02_AG亚型。 9名未接受联合抗逆转录病毒治疗（cART）的患者中有2名（22.2％）发现了对非核苷类逆转录酶抑制剂（NNRTIs）带有K103N和Y181C抗性突变的变异体。大多数HIV阳性患者（92.8％）显示出过去或现在存在HBV和/或HCV感染的证据。两种病毒的HBV和HCV患病率为81.2％，而HBV / HCV合并感染的患病率为69.6％。在意大利人中发现HCV感染的比例明显更高[比值比（OR）11.0；间隔1.7–80.9]和吸毒者（OR 27.8；间隔4.9–186.0）。在42名HCV或HBV / HCV合并感染的个体中确定了HCV亚型。 HCV亚型1a，3a，4d和1b在囚犯中分别占42.9％，40.5％，14.3％和2.4％。 HBV DNA阳性受试者的HBV DNA滴度低，因此无法进行HBV亚型分型.HIV感染囚犯中HBV和HCV合并感染的流行率高，以及HIV和HCV亚型的异质性表明，有必要在监狱中采取系统的控制措施来监控两者血源性病毒感染的负担和遗传形式，以便采取针对性的治疗干预措施。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号