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Concise Review: Organ Engineering: Design Technology and Integration

机译:简要评论:器官工程:设计技术和集成

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摘要

Engineering complex tissues and whole organs has the potential to dramatically impact translational medicine in several avenues. Organ engineering is a discipline that integrates biological knowledge of embryological development, anatomy, physiology, and cellular interactions with enabling technologies including biocompatible biomaterials and biofabrication platforms such as three-dimensional bioprinting. When engineering complex tissues and organs, core design principles must be taken into account, such as the structure-function relationship, biochemical signaling, mechanics, gradients, and spatial constraints. Technological advances in biomaterials, biofabrication, and biomedical imaging allow for in vitro control of these factors to recreate in vivo phenomena. Finally, organ engineering emerges as an integration of biological design and technical rigor. An overall workflow for organ engineering and guiding technology to advance biology as well as a perspective on necessary future iterations in the field is discussed.
机译:对复杂的组织和整个器官进行工程改造有可能在几种途径中极大地影响转化医学。器官工程学是一门学科,将胚胎发育,解剖学,生理学和细胞相互作用的生物学知识与使能技术包括生物相容性生物材料和生物制造平台(如三维生物打印)相结合。在设计复杂的组织和器官时,必须考虑核心设计原则,例如结构-功能关系,生化信号,力学,梯度和空间约束。生物材料,生物制造和生物医学成像方面的技术进步允许对这些因素进行体外控制,从而再现体内现象。最终,器官工程学成为生物学设计和严格技术的结合。讨论了器官工程学和指导技术以促进生物学发展的总体工作流程,以及对该领域未来必要的迭代方法的看法。

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