首页> 美国卫生研究院文献>other >Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function

【2h】

Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function

机译：相对于健康饮食饲喂高脂/糖饮食和不添加白藜芦醇的恒河猴壁顶叶的蛋白质组学比较：认识不健康饮食和白藜芦醇对功能的作用

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

A diet consisting of a high intake of saturated fat and refined sugars is characteristic of a Western-diet and has been shown to have a substantial negative effect on human health. Expression proteomics were used to investigate changes to the parietal lobe proteome of rhesus monkeys consuming either a high fat and sugar (HFS) diet, a HFS diet supplemented with resveratrol (HFS+RSV), or a healthy control diet for 2 years. Here we discuss the modifications in the levels of 12 specific proteins involved in various cellular systems including metabolism, neurotransmission, structural integrity, and general cellular signaling following a nutritional intervention. Our results contribute to a better understanding of the mechanisms by which resveratrol functions through the up- or down-regulation of proteins in different cellular sub-systems to affect the overall health of the brain.

机译：饮食中含有大量的饱和脂肪和精制糖，是西方饮食的特征，并且已显示对人体健康具有重大负面影响。表达蛋白质组学用于研究恒河猴食用高脂肪和高糖（HFS）饮食，补充白藜芦醇（HFS + RSV）的HFS饮食或健康对照饮食2年的顶叶蛋白质组的变化。在这里，我们讨论了营养干预后各种细胞系统（包括代谢，神经传递，结构完整性和一般细胞信号传导）所涉及的12种特定蛋白质水平的修饰。我们的结果有助于更好地了解白藜芦醇通过上调或下调蛋白质在不同细胞子系统中的功能机制，从而影响大脑的整体健康。

著录项

期刊名称 other
作者
Aaron M. Swomley; Judy C. Triplett; Jeriel T. Keeney; Govind Warrier; Kevin J. Pearson; Julie A. Mattison; Rafael de Cabo; Jian Cai; Jon B. Klein; D. Allan Butterfield;
展开▼
作者单位

展开▼
年(卷),期 -1(39),-1
年度 -1
页码 169–179
总页数 25
原文格式 PDF
正文语种
中图分类
关键词
Resveratrol Proteomics Western diet Rhesus monkey Brain;

机译：白藜芦醇;蛋白质组学;西方饮食;恒河猴;大脑;

相似文献

外文文献
中文文献

1. Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation, relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function [J] . Swomley Aaron M., Triplett Judy C., Keeney Jeriel T., The Journal of Nutritional Biochemistry . 2017,第期

机译：来自恒河猴的比较蛋白质组学分析喂养高脂肪/糖饮食，不含白藜芦醇补充剂，相对于健康饮食：洞察不健康饮食和白藜芦醇对功能的洞察力
2. Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation, relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function [J] . Aaron M. Swomley, Judy C. Triplett, Jeriel T. Keeney, The Journal of Nutritional Biochemistry . 2017,第期

机译：来自恒河猴的比较蛋白质组学分析喂养高脂肪/糖饮食，不含白藜芦醇补充剂，相对于健康饮食：洞察不健康饮食和白藜芦醇对功能的洞察力
3. Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation, relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function [J] . The Journal of Nutritional Biochemistry . 2017,第期

机译：来自恒河猴的比较蛋白质组学分析喂养高脂肪/糖饮食，不含白藜芦醇补充剂，相对于健康饮食：洞察不健康饮食和白藜芦醇对功能的洞察力
4. Global Metabolomic Profile Differentially Segregates with Calcium Supplementation in Mice Fed a High-Fat Western Style Diet [C] . Muhammad Aslam, Li Zhang, Christine Bassis, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：全球性代谢物谱差异偏析，小鼠钙补充剂喂养高脂肪西式饮食
5. Oxidative Stress and Proteomic Studies of Mammalian Models of Age-Related Metabolic Dysfunction in Neurodegenerative Disorders: (1) Upregulation of Pin1 in Alzheimer Mouse Model (2) Analysis of Brain Post-Intranasal Administration of Insulin in Alzheimer and Induced Diabetic Mouse Models (3) Analysis Of Proteome Changes In The Parietal Lobule Of Rhesus Monkey Non-Human Primate Following Resveratrol Supplementation as a Part of a Western-Diet. [D] . Swomley, Aaron Michael. 2017

机译：氧化应激和蛋白质组学研究的神经退行性疾病的年龄相关代谢功能障碍的哺乳动物模型：（1）阿尔茨海默病小鼠模型中Pin1的上调（2）鼻内注射胰岛素对老年性痴呆症小鼠和诱导的糖尿病小鼠模型的分析（3）白藜芦醇补充作为西方饮食的一部分，恒河猴非人类灵长类动物顶叶小叶蛋白质组变化的分析。
6. Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on a high-fat high-sugar diet [O] . Yolanda Jimenez-Gomez, Julie A. Mattison, Kevin J. Pearson, -1

机译：白藜芦醇可改善高脂高糖饮食的恒河猴脂肪组织中的胰岛素信号传导并减少其炎症反应
7. Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet [O] . Martín-Montalvo, Alejandro, Navas, Plácido, Bernier, Michel, 2013

机译：在高脂，高糖饮食下，白藜芦醇可改善恒河猴脂肪组织中的胰岛素信号传导并减少其炎症反应

Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function

摘要

著录项

相似文献

相关主题

期刊订阅