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EXPERIMENTALLY INCREASING TITIN’S COMPLIANCE THROUGH RBM20 INHIBITION IMPROVES DIASTOLIC FUNCTION IN A MOUSE MODEL OF HFpEF

机译：通过抑制RBM20的实验来提高TITIN的顺应性从而在HFpEF小鼠模型中改善舒张功能

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BackgroundLeft Ventricular (LV) stiffening contributes to Heart Failure with preserved Ejection Fraction (HFpEF), a syndrome with no effective treatment options. Increasing titin’s compliance in the heart has become possible recently through inhibition of the splicing factor RBM20. Here we investigated the effects of increasing titin’s compliance in mice with diastolic dysfunction.

机译：背景左心室（LV）僵硬会导致心力衰竭，其射血分数（HFpEF）保持不变，这是一种没有有效治疗选择的综合征。最近，通过抑制剪接因子RBM20，有可能提高心脏中的TITIN顺应性。在这里，我们研究了舒张功能障碍的小鼠体内增加维生素A依从性的作用。

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期刊名称 other
作者
Mei Methawasin; Joshua G Strom; Rebecca E Slater; Vanessa Fernandez; Chandra Saripalli; Henk Granzier;
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作者单位

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年(卷),期 -1(134),15
年度 -1
页码 1085–1099
总页数 26
原文格式 PDF
正文语种
中图分类
关键词
diastole titin HFpEF RBM20 passive stiffness;

机译：舒张期;泰坦;HFpEF;RBM20;被动刚度;

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专利

1. Response by Methawasin and Granzier to Letter Regarding Article, "Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function in a Mouse Model of Heart Failure With Preserved Ejection Fraction" [J] . Methawasin Mei, Granzier Henk Circulation: An Official Journal of the American Heart Association . 2017,第11期

机译：甲烷烃和格雷泽的回应关于文章的信，“通过RNA结合MOTIF-20（RBM20）抑制的三肽的依从性提高了抑制作用射血分数的心力衰竭小鼠模型中的舒张功能”
2. Letter by Lewis and Miller Regarding Article, "Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function in a Mouse Model of Heart Failure With Preserved Ejection Fraction" [J] . Lewis Gavin A., Miller Christopher A. Circulation: An Official Journal of the American Heart Association . 2017,第11期

机译：Lewis和Miller关于文章的信，“通过RNA结合MOTIF-20（RBM20）抑制的标题依从性提高了抑制作用射血射入部分的心力衰竭小鼠模型中的舒张功能”
3. Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function In a Mouse Model of Heart Failure With Preserved Ejection Fraction [J] . Methawasin Mei, Strom Joshua G., Slater Rebecca E., Circulation: An Official Journal of the American Heart Association . 2016,第15期

机译：通过RNA结合Motif-20（RBM20）抑制作用，实验性地提高Titin的顺应性，在保留射血分数的心力衰竭小鼠模型中改善舒张功能
4. INHIBITION OF BONE LOSS AND MUSCLE ATROPHY BY DYNAMIC MUSCLE CONTRACTIONS WITH REST PERIODS IN A FUNCTIONAL DISUSE MOUSE MODEL [C] . Adiba Ali, Yi-Xian Qin ASME summer bioengineering conference;SBC2008 . 2009

机译：功能性废弃小鼠模型中具有静止期的动态肌肉收缩对骨丢失和肌肉萎缩的抑制作用
5. Role of titin and collagen in the diastolic dysfunction of cirrhotic cardiomyopathy [D] . Glenn, Tamara 2008

机译：纤溶酶和胶原蛋白在肝硬化性心肌病舒张功能障碍中的作用
6. Response to Letter from Lewis and Miller regarding ArticleExperimentally Increasing the Compliance of Titin Through RNA BindingMotif-20 (RBM20) Inhibition Improves Diastolic function In a Mouse Model ofHeart Failure with Preserved Ejection Fraction [O] . Mei Methawasin, Henk Granzier -1

机译：回应Lewis和Miller关于Article的信函通过RNA结合实验性地增加了Titin的顺应性Motif-20（RBM20）抑制改善小鼠模型的舒张功能。保留射血分数的心力衰竭
7. Letter by Lewis and Miller Regarding Article, “Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function in a Mouse Model of Heart Failure With Preserved Ejection Fraction” [O] . Gavin A. Lewis, Christopher A. Miller 2017

机译：Lewis和Miller关于文章的信，“通过RNA结合MOTIF-20（RBM20）抑制的依次提高三肽的依从性提高了抑制作用射血分数的心力衰竭小鼠模型中的舒张功能”

EXPERIMENTALLY INCREASING TITIN’S COMPLIANCE THROUGH RBM20 INHIBITION IMPROVES DIASTOLIC FUNCTION IN A MOUSE MODEL OF HFpEF

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