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Arginase Inhibition Reverses Endothelial Dysfunction Pulmonary Hypertension and Vascular Stiffness in Transgenic Sickle Cell Mice

机译：精氨酸酶抑制逆转转基因镰状细胞小鼠的内皮功能障碍肺动脉高压和血管僵硬。

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BackgroundIn sickle cell disease (SCD), hemolysis results in the release and activation of arginase, an enzyme that reciprocally regulates nitric oxide (NO) synthase activity and thus, NO production. However, simply supplementing the common substrate L-arginine fails to improve NO bioavailability. In this study, we tested the hypothesis that arginase inhibition would improve NO bioavailability and thereby attenuate systemic and pulmonary vascular endothelial dysfunction in transgenic mice with SCD.

机译：背景技术在镰状细胞病（SCD）中，溶血导致精氨酸酶的释放和激活，精氨酸酶是一种相互调节一氧化氮（NO）合酶活性并因此调节NO产生的酶。然而，简单地补充普通底物L-精氨酸不能改善NO的生物利用度。在这项研究中，我们测试了精氨酸酶抑制将改善NO生物利用度从而减轻SCD转基因小鼠全身和肺血管内皮功能障碍的假说。

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期刊名称 other
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Jochen Steppan; Huong T Tran; Valeriani R Bead; Young Jun Oh; Gautam Sikka; Trinity J Bivalacqua; Arthur L Burnett; Dan E Berkowitz; Lakshmi Santhanam;
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年(卷),期 -1(123),3
年度 -1
页码 652–658
总页数 16
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1. Arginase Inhibition Reverses Endothelial Dysfunction, Pulmonary Hypertension, and Vascular Stiffness in Transgenic Sickle Cell Mice [J] . Steppan Jochen, Tran Huong T., Bead Valeriani R., Anesthesia and Analgesia: Journal of the International Anesthesia Research Society . 2016,第3期

机译：精氨酸酶抑制逆转转基因镰状细胞小鼠的内皮功能障碍，肺动脉高压和血管僵硬。
2. Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats. [J] . Kim JH, Bugaj LJ, Oh YJ Journal of applied physiology . 2009,第4期

机译：精氨酸酶抑制作用可恢复NOS偶联并逆转老龄大鼠的内皮功能障碍和血管僵硬。
3. Hypoxia does neither stimulate pulmonary artery endothelial cell proliferation in mice and rats with pulmonary hypertension and vascular remodeling nor in human pulmonary artery endothelial cells. [J] . Yu L, Hales CA Journal of vascular research . 2011,第6期

机译：低氧既不刺激患有肺动脉高压和血管重塑的小鼠和大鼠，也不刺激人肺动脉内皮细胞的肺动脉内皮细胞增殖。
4. Non-invasive indicators of pulmonary hypertension from pulmonary veins quantification in sickle cell disease [C] . Jajamovich Guido H., Pamulapati Vivek, Alam Shoaib, Biomedical Imaging (ISBI), 2012 9th IEEE International Symposium on . 2012

机译：镰状细胞病中肺静脉定量的非侵入性肺动脉高压指标
5. Dynamic system models to noninvasively predict pulmonary vascular stiffness, pulmonary vascular resistance, flow and heart work in children with pulmonary hypertension. [D] . Gross, Justin K. 2007

机译：动态系统模型可无创地预测肺动脉高压儿童的肺血管僵硬度，肺血管阻力，血流和心脏功能。
6. Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats [O] . Jae Hyung Kim, Lukasz J. Bugaj, Young Jun Oh, -1

机译：精氨酸酶抑制可恢复NOS偶联并逆转老龄大鼠的内皮功能障碍和血管僵硬
7. Arginase Inhibition Reverses Endothelial Dysfunction, Pulmonary Hypertension, and Vascular Stiffness in Transgenic Sickle Cell Mice [O] . Jochen Steppan, Huong T. Tran, Valeriani R. Bead, 2016

机译：氨基酶抑制在转基因镰状细胞小鼠中逆转内皮功能障碍，肺动脉高压和血管刚度

Arginase Inhibition Reverses Endothelial Dysfunction Pulmonary Hypertension and Vascular Stiffness in Transgenic Sickle Cell Mice

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