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TLR1/2 Activation during Heterologous Prime-Boost Vaccination (DNA-MVA) Enhances CD8+ T Cell Responses Providing Protection against Leishmania (Viannia)

机译：异源初次加强免疫接种期间的TLR1 / 2激活（DNA-MVA）增强CD8 + T细胞反应从而提供针对利什曼原虫病的保护（维尼亚）

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Background Leishmania (Viannia) parasites present particular challenges, as human and murine immune responses to infection are distinct from other Leishmania species, indicating a unique interaction with the host. Further, vaccination studies utilizing small animal models indicate that modalities and antigens that prevent infection by other Leishmania species are generally not protective.

机译：背景利什曼原虫（Viannia）的寄生虫面临着特殊的挑战，因为人类和鼠类对感染的免疫反应不同于其他利什曼原虫物种，表明与宿主的独特相互作用。此外，利用小型动物模型进行的疫苗接种研究表明，防止其他利什曼原虫感染的方式和抗原通常没有保护性。

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期刊名称 PLoS Neglected Tropical Diseases
作者
Asha Jayakumar; Tiago M. Castilho; Esther Park; Karen Goldsmith-Pestana; Jenefer M. Blackwell; Diane McMahon-Pratt;
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作者单位

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年(卷),期 2011(5),6
年度 2011
页码 e1204
总页数 11
原文格式 PDF
正文语种
中图分类寄生动物、寄生虫学;医学寄生虫学;
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专利

1. TLR1/2 Activation during Heterologous Prime-Boost Vaccination (DNA-MVA) Enhances CD8+ T Cell Responses Providing Protection against Leishmania (Viannia) [J] . Asha Jayakumar, Tiago M. Castilho, Esther Park, PLOS Neglected Tropical Diseases . 2011,第6期

机译：异源初免-加强免疫接种期间的TLR1 / 2激活（DNA-MVA）增强CD8 + T细胞反应，从而提供针对利什曼原虫病的保护（维尼亚）
2. Heterologous prime-boost vaccination with H3N2 influenza viruses of swine favors cross-clade antibody responses and protection [J] . Kristien Van Reeth, José Carlos Mancera Gracia, Ivan Trus, NPJ vaccines. . 2017,第1期

机译：猪H3N2流感病毒异源初免-加强疫苗接种有利于交叉抗体反应和保护
3. Heterologous prime-boost vaccination with a non-replicative vaccinia recombinant vector expressing LACK confers protection against canine visceral leishmaniasis with a predominant Th1-specific immune response [J] . Ramos I, Alonso A, Marcen JM, Vaccine . 2008,第3期

机译：用表达LACK的非复制牛痘重组载体进行异源初免-加强免疫接种可预防犬内脏利什曼病，并具有主要的Th1特异性免疫反应
4. Encapsulation of antigen in chitosan particles enhances activation and antigen specific response by antigen presenting cells [C] . Bhanuprasanth Koppolu, David A. Zaharoff Society for biomaterials annual meeting and exposition . 2013

机译：抗原在壳聚糖颗粒中的包裹增强了抗原呈递细胞的激活和抗原特异性反应
5. Prime-boost vaccine strategies using adenovirus and adeno-associated virus vectors to induce CD8+ T cell responses against human immunodeficiency virus type I [D] . Lin, Shih-Wen (Wenny) 2008

机译：使用腺病毒和腺伴随病毒载体的初免-加强疫苗策略诱导针对I型人免疫缺陷病毒的CD8 + T细胞应答
6. NKTi cell activation during DNA priming in heterologous prime-boost vaccination enhances T cell responses and protection against Leishmania [O] . Blaise Dondji, Eszter Deak, Karen Goldsmith-Pestana, -1

机译：异源初免-加强接种中的DNA初免期间的NKTi细胞激活增强了T细胞应答并保护了利什曼原虫
7. TLR1/2 Activation during Heterologous Prime-Boost Vaccination (DNA-MVA) Enhances CD8+ T Cell Responses Providing Protection against Leishmania (Viannia) [O] . Jayakumar, Asha, Castilho, Tiago M., Park, Esther, 2011

机译：异源初次加强免疫接种期间的TLR1 / 2激活（DNA-MVA）增强CD8 + T细胞反应，从而提供针对利什曼原虫病的保护（维尼亚）

TLR1/2 Activation during Heterologous Prime-Boost Vaccination (DNA-MVA) Enhances CD8+ T Cell Responses Providing Protection against Leishmania (Viannia)

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