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首页> 美国卫生研究院文献>The Journal of Experimental Medicine >PHENOMENON OF LOCAL SKIN REACTIVITY TO BACTERIAL FILTRATES: EFFECT OF BACTERIAL FILTRATES INJECTED INTRAVASCULARLY UPON REACTIONS TO ANTIGEN + ANTIBODY COMPLEXES
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PHENOMENON OF LOCAL SKIN REACTIVITY TO BACTERIAL FILTRATES: EFFECT OF BACTERIAL FILTRATES INJECTED INTRAVASCULARLY UPON REACTIONS TO ANTIGEN + ANTIBODY COMPLEXES

机译：局部皮肤对细菌性滤过物的反应现象：细菌性滤过物对抗原+抗体复合物的血管内注射作用。

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Rabbits were sensitized by a single intravenous injection of horse serum 6 days prior to the experiments. In these rabbits there appeared hemorrhagic and necrotic reactions in sites of intradermal tests with horse serum when the tests were preceded by 1 hour, or followed 18 to 24 hours later by an intravenous injection of potent bacterial filtrates. The skin-preparatory and reacting potencies of the filtrates were titrated by means of the phenomenon of local skin reactivity to bacterial filtrate. The experiments demonstrated that the ability of bacterial filtrates to elicit reactions in the antigen injected sites in sensitized animals is strictly conditioned by their skin-preparatory potency and seems to be quite independent of their provocative potency. Combinations of animal protein antigens with homologous antisera, which are endowed with provocative potency but are totally devoid of skin-preparatory potency, fail to elicit reactions in antigen-injected sites. The various methods of elicitation of the phenomenon of local tissue reactivity are summarized and discussed in the text.
机译：实验前6天，通过单次静脉内注射马血清使兔子致敏。在这些兔子中，用马血清进行皮内试验时，在试验进行1小时之前或在静脉注射有效细菌滤液后18至24小时出现出血和坏死反应。通过局部皮肤对细菌滤液的反应现象来滴定滤液的皮肤制备能力和反应能力。实验表明，细菌滤液在致敏动物的抗原注射部位引发反应的能力严格取决于其皮肤制备能力，并且似乎与它们的激发能力完全无关。动物蛋白抗原与同源抗血清的结合具有激发作用，但完全没有皮肤制备作用，无法在抗原注射部位引发反应。文中总结并讨论了引起局部组织反应性现象的各种方法。

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