SOME PROPERTIES OF THE ENCEPHALOPATHIC AGENT IN PRIMATE BONE MARROW (THE GORDON AGENT)

机译：脑脊髓疾病中脑病药物的某些性质（戈登药物）

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The nature of the encephalopathic agent present in monkey bone marrow has been investigated. It is readily soluble at a pH of 7.4, as well as at the low pH of 2.0 and 3.0. The point of minimal solubility is pH 4.2. Heat inactivation is produced by a temperature of 75°C., acting for 15 minutes. The agent is digested by pepsin. It exhibits a slight degree of sedimentation with the air-driven centrifuge. It is non-dialyzable. It is precipitated from solution (pH 7.4) by ammonium sulfate, over a range of 0.4 to 0.8 saturation. These findings all suggest that the agent is a protein. No immunological reactions could be elicited.

机译：已经研究了猴骨髓中存在的脑病药物的性质。在pH值为7.4以及低pH值为2.0和3.0时很容易溶解。最小溶解度的点是pH 4.2。 75℃的温度作用15分钟产生热失活。该药剂被胃蛋白酶消化。空气离心机显示出轻微的沉淀。它是不可透析的。在0.4至0.8的饱和度范围内，硫酸铵从溶液（pH 7.4）中沉淀出。这些发现都表明该药剂是蛋白质。没有引起免疫反应。

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期刊名称 The Journal of Experimental Medicine
作者
Lester S. King;
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作者单位

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年(卷),期 1940(71),5
年度 1940
页码 603–618
总页数 17
原文格式 PDF
正文语种
中图分类免疫学;医学史;
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6. 202. The effectiveness of combination therapy of anti-methicillin-resistant Staphylococcus aureus agents and β-lactam agents in patients complicated with febrile neutropenia after bone marrow transplantation [O] . Soichiro Sugiyama, Hiroyuki Shimizu, Shinya Hashimoto, -1

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7. SOME PROPERTIES OF THE ENCEPHALOPATHIC AGENT IN PRIMATE BONE MARROW (THE GORDON AGENT) [O] . King, Lester S. 1940

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SOME PROPERTIES OF THE ENCEPHALOPATHIC AGENT IN PRIMATE BONE MARROW (THE GORDON AGENT)

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