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Enhanced cartilage repair in ‘healer’ mice—New leads in the search for better clinical options for cartilage repair

机译:增强愈疗者小鼠的软骨修复-寻找更好的软骨修复临床选择的新线索

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摘要

Adult articular cartilage has a poor capacity to undergo intrinsic repair. Current strategies for the repair of large cartilage defects are generally unsatisfactory because the restored cartilage does not have the same resistance to biomechanical loading as authentic articular cartilage and degrades over time. Recently, an exciting new research direction, focused on intrinsic cartilage regeneration rather than fibrous repair by external means, has emerged. This review explores the new findings in this rapidly moving field as they relate to the clinical goal of restoration of structurally robust, stable and non-fibrous articular cartilage following injury.
机译:成人关节软骨进行固有修复的能力较弱。当前修复大软骨缺损的策略通常不能令人满意,因为恢复的软骨对生物机械负荷的抵抗力不如真实的关节软骨,并且随着时间的推移而退化。最近,出现了一个激动人心的新研究方向,其重点是固有软骨再生,而不是通过外部手段修复纤维。这篇综述探讨了这一快速发展领域中的新发现,因为它们与损伤后恢复结构坚固,稳定和非纤维性关节软骨的临床目标有关。

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