• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>other >Experimental Observation of the Asymmetric Instability of Intermediate-Reduced-Volume Vesicles in Extensional Flow
【2h】

Experimental Observation of the Asymmetric Instability of Intermediate-Reduced-Volume Vesicles in Extensional Flow

机译：扩流中体积减小的囊泡不对称失稳的实验观察

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Vesicles provide an attractive model system to understand the deformation of living cells in response to mechanical forces. These simple, enclosed lipid bilayer membranes are suitable for complementary theoretical, numerical, and experimental analysis. A recent study [Narsimhan, Spann, Shaqfeh, Journal of Fluid Mechanics, 2014, >750, 144] predicted that intermediate-aspect-ratio vesicles extend asymmetrically in extensional flow. Upon infinitesimal perturbation to the vesicle shape, the vesicle stretches into an asymmetric dumbbell with a cylindrical thread separating the two ends. While the symmetric stretching of high-aspect-ratio vesicles in extensional flow has been observed and characterized [Kantsler, Segre, Steinberg, Physics Review Letters, 2008, >101, 048101] as well as recapitulated in numerical simulations by Narsimhan et al., experimental observation of the asymmetric stretching has not been reported. In this work, we present results from microfluidic cross-slot experiments observing this instability, along with careful characterization of the flow field, vesicle shape, and vesicle bending modulus. The onset of this shape transition depends on two non-dimensional parameters: reduced volume (a measure of vesicle asphericity) and capillary number (ratio of viscous to bending forces). We observed that every intermediate-reduced-volume vesicle that extends forms a dumbbell shape that is indeed asymmetric. For the subset of the intermediate-reduced-volume regime we could capture experimentally, we present an experimental phase diagram for asymmetric vesicle stretching that is consistent with the predictions of Narsimhan et al.
机译：囊泡提供了吸引人的模型系统，以了解活细胞响应机械力的变形。这些简单的封闭式脂质双层膜适用于互补的理论，数值和实验分析。最近的一项研究[Narsimhan，Spann，Shaqfeh，Journal of Fluid Mechanics，2014，> 750 ，144]预测，中间纵横比的囊泡在伸展流中不对称地伸展。在对囊泡形状进行无穷微扰动后，囊泡会拉伸成不对称的哑铃，哑铃形的圆柱线将两端分开。虽然已经观察到并表征了高纵横比囊泡在拉伸流中的对称拉伸[Kantsler，Segre，Steinberg，Physics Review Letters，2008，> 101 ，048101]并在数值模拟中进行了概括Narsimhan等人的研究还没有报道不对称拉伸的实验观察。在这项工作中，我们提出了微流体交叉槽实验的结果，观察了这种不稳定性，并仔细表征了流场，囊泡形状和囊泡弯曲模量。这种形状转变的开始取决于两个非尺寸参数：减小的体积（一种测量的囊泡非球面性）和毛细管数（粘性与弯曲力之比）。我们观察到，每个中间体积减小的囊泡延伸形成的哑铃形状实际上是不对称的。对于中间减少体积状态的子集，我们可以通过实验捕获，我们提出了不对称囊泡拉伸的实验相图，与Narsimhan等人的预测一致。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号