• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>other >Evaluation of the Activity of the Essential Oil from an Ornamental Flower against Aedes aegypti: Electrophysiology Molecular Dynamics and Behavioral Assays
【2h】

Evaluation of the Activity of the Essential Oil from an Ornamental Flower against Aedes aegypti: Electrophysiology Molecular Dynamics and Behavioral Assays

机译：观赏花卉精油对埃及伊蚊的活性评估：电生理分子动力学和行为分析

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Dengue fever has spread worldwide and affects millions of people every year in tropical and subtropical regions of Africa, Asia, Europe and America. Since there is no effective vaccine against the dengue virus, prevention of disease transmission depends entirely on regulating the vector (Aedes aegypti) or interrupting human-vector contact. The aim of this study was to assess the oviposition deterrent activity of essential oils of three cultivars of torch ginger (Etlingera elatior, Zingiberaceae) against the dengue mosquito. Analysis of the oils by gas chromatography (GC)—mass spectrometry revealed the presence of 43 constituents, of which α-pinene, dodecanal and n-dodecanol were the major components in all cultivars. Solutions containing 100 ppm of the oils exhibited oviposition deterrent activities against gravid Ae. aegypti females. GC analysis with electroantennographic detection indicated that the oil constituents n-decanol, 2-undecanone, undecanal, dodecanal, trans-caryophyllene, (E)-β-farnesene, α-humulene, n-dodecanol, isodaucene and dodecanoic acid were able to trigger antennal depolarization in Ae. aegypti females. Bioassays confirmed that solutions containing 50 ppm of n-dodecanol or dodecanal exhibited oviposition deterrent activities, while a solution containing the alcohol and aldehyde in admixture at concentrations representative of the oil presented an activity similar to that of the 100 ppm oil solution. Docking and molecular dynamics simulations verified that the interaction energies of the long-chain oil components and Ae. aegypti odorant binding protein 1 were quite favorable, indicating that the protein is a possible oviposition deterrent receptor in the antenna of Ae. aegypti.
机译：登革热已在世界范围内传播，每年在非洲，亚洲，欧洲和美洲的热带和亚热带地区影响数百万人。由于没有针对登革热病毒的有效疫苗，因此，疾病传播的预防完全取决于调节载体（埃及伊蚊）或中断人与载体的接触。这项研究的目的是评估三种火炬姜（Etlingera elatior，姜科）的精油对登革热蚊子的产卵抑制作用。通过气相色谱（GC）-质谱法对油进行分析，发现存在43种成分，其中α-pine烯，十二烷和正十二烷醇是所有品种的主要成分。含有100 ppm的油的溶液表现出对妊娠Ae的产卵抑制作用。埃及女性。用电血管造影检查进行的GC分析表明，油成分正癸醇，2-十一烷酮，十一烷，十二烷，反式石竹烯，（E）-β-法呢烯，α-hu烯，正十二烷醇，异十二烷和十二烷酸均可以触发Ae中的触角去极化。埃及女性。生物测定法证实，含有50 ppm正十二烷醇或十二烷的溶液显示出抑制产卵的活性，而含有酒精和醛的混合溶液（代表油的浓度）则表现出与100 ppm油溶液相似的活性。对接和分子动力学模拟验证了长链油组分与Ae的相互作用能。埃及臭味剂结合蛋白1非常受欢迎，表明该蛋白是Ae触角中可能的产卵抑制因子。埃及。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号