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首页> 美国卫生研究院文献>Journal of Food Science and Technology >Evaluation of hepatoprotective and antioxidant activity of astaxanthin and astaxanthin esters from microalga-Haematococcus pluvialis
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Evaluation of hepatoprotective and antioxidant activity of astaxanthin and astaxanthin esters from microalga-Haematococcus pluvialis

机译：微藻-红血球菌中虾青素和虾青素酯的保肝和抗氧化活性评估

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摘要

Effect of isolated astaxanthin (ASX) and astaxanthin esters (ASXEs) from green microalga-Haematococcus pluvialis on hepatotoxicity and antioxidant activity against carbon tetrachloride (CCl4) induced toxicity in rats was compared with synthetic astaxanthin (SASX). ASX, ASXEs, and SASX, all dissolved in olive oil, fed to rats with 100 and 250 μg/kg b.w for 14 days. They were evaluated for their hepatoprotective and antioxidant activity by measuring appropriate enzymes. Among the treated groups, the SGPT, SGOT and ALP levels were decreased by 2, 2.4, and 1.5 fold in ASXEs treated group at 250 μg/Kg b.w. when compared to toxin group. Further, antioxidant enzymes catalase, glutathione, superoxide dismutase and lipid peroxidase levels were estimated in treated groups, their levels were reduced by 30–50 % in the toxin group, however these levels restored by 136.95 and 238.48 % in ASXEs treated group at 250 μg/kg. The lipid peroxidation was restored by 5.2 and 2.8 fold in ASXEs and ASX treated groups at 250 μg/kg. The total protein, albumin and bilirubin contents were decreased in toxin group, whereas normalized in ASXEs treated group. These results indicates that ASX and ASXEs have better hepatoprotection and antioxidant activity, therefore can be used in pharmaceutical and nutraceutical applications and also extended to use as food colorant.
机译：将绿色微藻-红血球菌的分离虾青素（ASX）和虾青素酯（ASXE）对大鼠的肝毒性和对四氯化碳（CCl4）诱导的毒性的抗氧化活性与合成虾青素（SASX）进行了比较。 ASX，ASXE和SASX均溶于橄榄油，以100和250μg/ kg体重的体重喂食大鼠14天。通过测量适当的酶评估他们的肝保护和抗氧化活性。在治疗组中，ASXE治疗组的SGPT，SGOT和ALP水平以250μg/ Kg b.w降低了2倍，2.4倍和1.5倍。与毒素组相比。此外，估计治疗组中的抗氧化酶过氧化氢酶，谷胱甘肽，超氧化物歧化酶和脂质过氧化物酶水平，在毒素组中降低了30–50％，但是在250μgASXEs治疗组中，这些水平恢复了136.95和238.48％。 /公斤。在ASXE和ASX处理组中，250μg/ kg的脂质过氧化恢复了5.2和2.8倍。毒素组总蛋白，白蛋白和胆红素含量降低，而ASXEs治疗组正常。这些结果表明ASX和ASXE具有更好的肝保护和抗氧化活性，因此可用于药物和营养保健品，也可扩展用作食品着色剂。

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