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CSF markers of Alzheimer’s pathology and microglial activation are associated with altered white matter microstructure in asymptomatic adults at risk for Alzheimer’s disease

机译：患有阿尔茨海默氏病风险的无症状成年人的脑脊液标志物可用于阿尔茨海默氏病的病理学和小胶质细胞活化与白质微观结构的改变有关

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BackgroundThe immune response in Alzheimer’s disease (AD) involves activation of microglia which may remove β-amyloid. However, overproduction of inflammatory compounds may exacerbate neural damage in Alzheimer’s disease. AD pathology accumulates years before diagnosis, yet the extent to which neuroinflammation is involved in the earliest disease stages is unknown.

机译：背景阿尔茨海默氏病（AD）的免疫反应涉及激活小胶质细胞，这可能会去除β-淀粉样蛋白。但是，炎性化合物的过量产生可能加剧阿尔茨海默氏病的神经损伤。 AD病理学在诊断之前已经积累了多年，但尚不清楚神经炎症在早期疾病阶段所涉及的程度。

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期刊名称 other
作者
Kelsey E Melah; Sharon Yuan-Fu Lu; Siobhan M Hoscheidt; Andrew L Alexander; Nagesh Adluru; Daniel J Destiche; Cynthia M Carlsson; Henrik Zetterberg; Kaj Blennow; Ozioma C Okonkwo; Carey E Gleason; N Maritza Dowling; Lisa C Bratzke; Howard A Rowley; Mark A Sager; Sanjay Asthana; Sterling C Johnson; Barbara B Bendlin;
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年(卷),期 -1(50),3
年度 -1
页码 873–886
总页数 24
原文格式 PDF
正文语种
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关键词
Alzheimer’s disease Inflammation Diffusion Tensor Imaging Cerebrospinal Fluid Proteins;

机译：阿尔茨海默氏病;发炎;扩散张量成像;脑脊液蛋白;

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专利

1. Cerebrospinal Fluid Markers of Alzheimer's Disease Pathology and Microglial Activation are Associated with Altered White Matter Microstructure in Asymptomatic Adults at Risk for Alzheimer's Disease [J] . Melah Kelsey E., Lu Sharon Yuan-Fu, Hoscheidt Siobhan M., Journal of Alzheimer's disease: JAD . 2016,第3期

机译：阿尔茨海默氏病病理和小胶质细胞活化的脑脊液标记物与无症状成年人中患阿尔茨海默氏病风险的白色物质微观结构改变有关
2. Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults. [J] . Braskie MN, Jahanshad N, Stein JL, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2011,第18期

机译：CLU基因中常见的阿尔茨海默氏病风险变异会影响年轻成年人的白质微观结构。
3. CSF beta-amyloid and white matter damage: unravelling the neuropathology of Alzheimer's disease [J] . Alves Gilberto Sousa Journal of Neurology, Neurosurgery and Psychiatry . 2018,第4期

机译：CSFβ-淀粉样蛋白和白质损伤：解开阿尔茨海默病的神经病理学
4. PARP1 Gene Variation and Microglial Activity on ~(11)CPBR28 PET in Older Adults at Risk for Alzheimer's Disease [C] . Sungeun Kim, Kwangsik Nho, Shannon L. Risacher, Multimodal brain image analysis . 2013

机译：〜（11）C PBR28 PET在老年痴呆症风险中的PARP1基因变异和小胶质细胞活性
5. Microglial Activation in the Hippocampus and the Cortex in Animal Model of Alzheimer's Disease Neuropathology. [D] . Upadhyay, Ankur D. 2013

机译：在阿尔茨海默氏病神经病理学动物模型中海马和皮层中的小胶质细胞活化。
6. CSF T-Tau/Aβ42 Predicts White Matter Microstructure in Healthy Adults at Risk for Alzheimer’s Disease [O] . Barbara B. Bendlin, Cynthia M. Carlsson, Sterling C. Johnson, 2009

机译：CSF T-Tau /Aβ42预测处于患阿尔茨海默氏病风险的健康成年人中的白色物质微观结构
7. CSF T-Tau/Aβ42 Predicts White Matter Microstructure in Healthy Adults at Risk for Alzheimer’s Disease [O] . Bendlin, Barbara B., Carlsson, Cynthia M., Johnson, Sterling C., 2012

机译：CSF T-Tau /Aβ42预测处于患阿尔茨海默氏病风险的健康成年人的白色物质微观结构

CSF markers of Alzheimer’s pathology and microglial activation are associated with altered white matter microstructure in asymptomatic adults at risk for Alzheimer’s disease

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