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首页> 美国卫生研究院文献>other >Novel Human Intervertebral Disc Strain Template to Quantify Regional Three-Dimensional Strains in a Population and Compare to Internal Strains Predicted by a Finite Element Model
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Novel Human Intervertebral Disc Strain Template to Quantify Regional Three-Dimensional Strains in a Population and Compare to Internal Strains Predicted by a Finite Element Model

机译：新型人类椎间盘应变模板以量化人口中的区域三维菌株并与有限元模型预测的内部菌株进行比较

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摘要

Tissue strain is an important indicator of mechanical function, but is difficult to noninvasively measure in the intervertebral disc. The objective of this study was to generate a disc strain template, a 3D average of disc strain, of a group of human L4–L5 discs loaded in axial compression. To do so, magnetic resonance images of uncompressed discs were used to create an average disc shape. Next, the strain tensors were calculated pixel-wise by using a previously developed registration algorithm. Individual disc strain tensor components were then transformed to the template space and averaged to create the disc strain template. The strain template reduced individual variability while highlighting group trends. For example, higher axial and circumferential strains were present in the lateral and posterolateral regions of the disc, which may lead to annular tears. This quantification of group-level trends in local 3D strain is a significant step forward in the study of disc biomechanics. These trends were compared to a finite element model that had been previously validated against the disc-level mechanical response. Depending on the strain component, 81–99% of the regions within the finite element model had calculated strains within one standard deviation of the template strain results. The template creation technique provides a new measurement technique useful for a wide range of studies, including more complex loading conditions, the effect of disc pathologies and degeneration, damage mechanisms, and design and evaluation of treatments.
机译：组织应变是机械功能的重要指标，但很难在椎间盘中进行非侵入性测量。这项研究的目的是生成一组承受轴向压缩的L4–L5人体椎间盘的椎间盘应变模板，即椎间盘应变的3D平均值。为此，未压缩光盘的磁共振图像用于创建平均光盘形状。接下来，使用先前开发的配准算法以像素为单位计算应变张量。然后将各个圆盘应变张量分量转换到模板空间并取平均值以创建圆盘应变模板。应变模板减少了个体差异，同时突出了群体趋势。例如，在椎间盘的侧面和后外侧区域存在较高的轴向和周向应变，这可能导致环形撕裂。局部3D应变中组水平趋势的这种量化是研究椎间盘生物力学的重要一步。将这些趋势与先前已针对磁盘级机械响应进行验证的有限元模型进行了比较。根据应变分量，有限元模型内81–99％的区域计算出的应变在模板应变结果的一个标准偏差内。模板创建技术提供了一种新的测量技术，可用于广泛的研究，包括更复杂的加载条件，椎间盘疾病和变性的影响，损伤机制以及治疗的设计和评估。

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