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CD4 count based failure criteria combined with viral load monitoring may trigger worse switch decisions than viral load monitoring alone

机译：基于CD4计数的故障标准与病毒载量监控相结合可能会导致比单独的病毒载量监控更糟糕的决策

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摘要

Objective:CD4 count decline often triggers antiretroviral regimen switches in resource limited settings, even when viral load testing is available. We therefore compared CD4 failure and CD4 trends in patients with viremia with or without antiretroviral resistance.

机译：目的：即使在进行病毒载量测试时，CD4计数下降通常也会在资源有限的环境中触发抗逆转录病毒疗法方案的转换。因此，我们比较了有或没有抗逆转录病毒耐药性的病毒血症患者的CD4衰竭和CD4趋势。

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期刊名称 other
作者
Christopher J HOFFMANN; Jean MARITZ; Gert U VAN ZYL;
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年(卷),期 -1(21),2
年度 -1
页码 219–223
总页数 9
原文格式 PDF
正文语种
中图分类
关键词
First-line antiretroviral therapy immunologic failure criteria HIV-1 viral load testing HIV-1 drug resistance adherence M184V Major NNRTI drug resistance mutations;

机译：一线抗逆转录病毒疗法;免疫学失败标准;HIV-1病毒载量测试;HIV-1耐药性;依从性;M184V;重大NNRTI耐药性突变;

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专利

1. CD4 count-based failure criteria combined with viral load monitoring may trigger worse switch decisions than viral load monitoring alone [J] . Hoffmann Christopher J., Maritz Jean, van Zyl Gert U. Tropical Medicine and International Health: TM and IH . 2016,第2期

机译：基于CD4计数的故障标准与病毒载量监控相结合可能会导致比单独的病毒载量监控更糟糕的切换决策
2. Switching HIV Treatment in Adults Based on CD4 Count Versus Viral Load Monitoring: A Randomized, Non-Inferiority Trial in Thailand [J] . Gonzague Jourdain, Sophie Le C?ur, Nicole Ngo-Giang-Huong, PLoS Medicine . 2013,第8期

机译：基于CD4计数与病毒载量监测的成人HIV治疗切换：泰国的一项随机，非自卑性试验
3. Monitoring of HIV viral load, CD4 cell count, and clinical assessment versus clinical monitoring alone for antiretroviral therapy in low-resource settings (Stratall ANRS 12110/ESTHER): A cost-effectiveness analysis [J] . BoyerS., MarchL., KouanfackC., The Lancet infectious diseases . 2013,第7期

机译：在资源贫乏地区监测HIV病毒载量，CD4细胞计数，并进行临床评估与单独进行抗逆转录病毒疗法的临床监测（Stratall ANRS 12110 / ESTHER）：成本效益分析
4. SVM-enabled prognostic method for clinical decision making: The use of CD4 T-cell level and HIV-1 viral load for guiding treatment initiation and alteration [C] . Kasmiran Khairul A, Zomaya Albert Y, Mazari Ali A, 23rd IEEE International Symposium on Computer-Based Medical Systems . 2010

机译：支持SVM的临床决策预后方法：使用CD4 T细胞水平和HIV-1病毒载量指导治疗的开始和改变
5. Adherence to Antiretroviral Therapy Among Adolescents and Young Adults Living with HIV in Haiti: Point-Of-Care Viral Load Testing to Simplify Viral Load Monitoring and Improve Outcomes [D] . Reif, Lindsey Krull. 2020

机译：在海地艾滋病病毒期间的青少年和年轻成年人中依赖抗逆转录病毒治疗：护理点病毒载体测试，以简化病毒载荷监测和改善结果
6. Switching HIV Treatment in Adults Based on CD4 Count Versus Viral Load Monitoring: A Randomized Non-Inferiority Trial in Thailand [O] . Gonzague Jourdain, Sophie Le Cœur, Nicole Ngo-Giang-Huong, 2013

机译：基于CD4计数与病毒载量监测的成人HIV治疗切换：泰国的一项随机非自卑性试验
7. Switching HIV Treatment in Adults Based on CD4 Count Versus Viral Load Monitoring: A Randomized, Non- Inferiority Trial in Thailand [O] . Monitoring A R, Non-inferiority Trial In Thail, Citable Link, 2016

机译：基于CD4计数与病毒载量监测成人转换成人艾滋病治疗：泰国的一项随机，非劣效性试验

CD4 count based failure criteria combined with viral load monitoring may trigger worse switch decisions than viral load monitoring alone

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