• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>other >Halloysite nanotube coatings suppress leukocyte spreading
【2h】

Halloysite nanotube coatings suppress leukocyte spreading

机译：埃洛石纳米管涂层抑制白细胞扩散

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The nanoscale topography of adhesive surfaces is known to be an important factor governing cellular behavior. Previous work has shown that surface coatings composed of halloysite nanotubes enhances the adhesion, and therefore capture, of rare target cells such as circulating tumor cells. Here, we demonstrate a unique feature of these coatings in its ability to reduce the adhesion of leukocytes and prevent leukocyte spreading. Surfaces were prepared with coatings of halloysite nanotubes and functionalized for leukocyte adhesion with E-selectin, and the dilution of nanotube concentration revealed a threshold concentration below which cell spreading became comparable with smooth surfaces. Evaluation of surface roughness characteristics determined that the average distance between discrete surface features correlated with adhesion metrics, with a separation distance of approximately 2 μm identified as the critical threshold. Computational modeling of the interaction of leukocytes with halloysite nanotube coated surfaces of varying concentrations demonstrates that the geometry of the cell surface and adhesive counter-surface produce a significantly diminished effective contact area compared to a leukocyte interacting with a smooth surface.
机译：已知粘合剂表面的纳米级形貌是控制细胞行为的重要因素。先前的工作表明，由埃洛石纳米管组成的表面涂层可增强稀有靶细胞（如循环肿瘤细胞）的粘附力，并因此而捕获。在这里，我们证明了这些涂层在减少白细胞黏附和防止白细胞扩散方面的独特功能。用埃洛石纳米管涂层制备表面，并用E-选择素对白细胞粘附进行功能化，纳米管浓度的稀释显示出阈值浓度，低于该阈值浓度，细胞扩散变得与光滑表面相当。对表面粗糙度特征的评估确定，离散表面特征之间的平均距离与附着力度量相关，大约2μm的分离距离被确定为临界阈值。白细胞与不同浓度的埃洛石纳米管涂层表面相互作用的计算模型表明，与与光滑表面相互作用的白细胞相比，细胞表面和粘合剂反表面的几何形状产生显着减小的有效接触面积。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号