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A Pilot Study of pNGVL4a-CRT/E7(detox) for the Treatment of Patients with HPV16+ Cervical Intraepithelial Neoplasia 2/3 (CIN2/3)

机译：pNGVL4a-CRT / E7（排毒）治疗HPV16 +宫颈上皮内瘤样增生2/3（CIN2 / 3）的临床研究

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摘要

ObjectiveThe purpose of this study was to evaluate the safety, efficacy, and immunogenicity of a plasmid vaccine, pNGVL4a-CRT-E7(detox), administered either intradermally, intramuscularly, or directly into the cervical lesion, in patients with HPV16-associated CIN2/3.

机译：目的本研究的目的是评估与HPV16相关的CIN2 /患者皮内，肌内或直接进入宫颈病变的质粒疫苗pNGVL4a-CRT-E7（detox）的安全性，有效性和免疫原性3。

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期刊名称 other
作者
Ronald D. Alvarez; Warner K. Huh; Sejong Bae; Lawrence S. Lamb Jr.; Michael G. Conner; Jean Boyer; Chenguang Wang; Chien-Fu Hung; Elizabeth Sauter; Mihaela Paradis; Emily A. Adams; Shirley Hester; Bradford E. Jackson; T.C. Wu; Cornelia Trimble;
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年(卷),期 -1(140),2
年度 -1
页码 245–252
总页数 22
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专利

1. 子宫颈上皮内瘤样病变和子宫颈癌组织中Smad2/3和HPV16 E7的表达及意义 [J] . 田媛, 吴鹏, 罗爱月, 癌症（英文版） . 2007,第009期
2. A pilot study of pNGVL4a-CRT/E7(detox) for the treatment of patients with HPV16+cervical intraepithelial neoplasia 2/3 (CIN2/3) [J] . Alvarez Ronald D., Huh Warner K., Bae Sejong, Gynecologic Oncology: An International Journal . 2016,第2期

机译：pNGVL4a-CRT / E7（排毒）治疗HPV16 +宫颈上皮内瘤样增生2/3（CIN2 / 3）的中试研究
3. Oral vaccination against HPV E7 for treatment of cervical intraepithelial neoplasia grade 3 (CIN3) elicits E7-specific mucosal immunity in the cervix of CIN3 patients [J] . Kawana Kei, Adachi Katsuyuki, Kojima Satoko, Vaccine . 2014,第47期

机译：针对HPV E7的口服疫苗治疗宫颈上皮内瘤样变3级（CIN3）在CIN3患者的子宫颈中引起E7特异性粘膜免疫
4. Intraoperative post-conisation human papillomavirus testing for early detection of treatment failure in patients with cervical intraepithelial neoplasia: A pilot study [J] . TornéA., FustéP., Rodríguez-CarunchioL., BJOG: an international journal of obstetrics and gynaecology . 2013,第4期

机译：宫颈内上皮内瘤变患者术中锥后乳头瘤病毒检测以早期发现治疗失败的试验研究
5. Elimination of Cervical Intraepithelial Neoplasia I with Photodynamic Therapy for Patients Resisting a First Irradiation [C] . Maria Teresa López Cárdenas, Araceli Espinosa Montesinos, Elizabeth Maldonado Alvarado, Mexican Symposium on Medical Physics . 2019

机译：消除宫颈上皮内瘤瘤I具有光动力治疗，抵抗第一次辐照的患者
6. Identification and functional analysis of HPV-16 E7 HLA-DR restricted epitopes in patients with cervical neoplasia or cancer. [D] . Warrino, Dominic. 2004

机译：宫颈癌或癌症患者中HPV-16 E7 HLA-DR限制性表位的鉴定和功能分析。
7. The Trained Sniffer Dog Could Accurately Detect the Urine Samples from the Patients with Cervical Cancer and Even Cervical Intraepithelial Neoplasia Grade 3: A Pilot Study [O] . Akihito Yamamoto, Seiryu Kamoi, Keisuke Kurose, 2020

机译：训练有素的嗅探犬可以准确地检测宫颈癌患者的尿液样本甚至宫颈上皮内瘤级3级：试点研究
8. The Trained Sniffer Dog Could Accurately Detect the Urine Samples from the Patients with Cervical Cancer, and Even Cervical Intraepithelial Neoplasia Grade 3: A Pilot Study [O] . Akihito Yamamoto, Seiryu Kamoi, Keisuke Kurose, 2020

机译：训练有素的嗅探犬可以准确地检测宫颈癌患者的尿液样本，甚至宫颈上皮内瘤级3级：试点研究

A Pilot Study of pNGVL4a-CRT/E7(detox) for the Treatment of Patients with HPV16+ Cervical Intraepithelial Neoplasia 2/3 (CIN2/3)

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