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首页> 美国卫生研究院文献>other >Diagnostic Yield of FDG-PET/CT MRI and CSF Cytology in Non-Biopsiable Neurolymphomatosis as a Heralding Sign of Recurrent Non-Hodgkins Lymphoma
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Diagnostic Yield of FDG-PET/CT MRI and CSF Cytology in Non-Biopsiable Neurolymphomatosis as a Heralding Sign of Recurrent Non-Hodgkins Lymphoma

机译：FDG-PET / CTMRI和CSF细胞学检查在非活检性神经淋巴瘤病中的诊断收率是复发性非霍奇金淋巴瘤的预兆

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摘要

Neurolymphomatosis (NL) is a rare condition associated with lymphomas in which various structures of the nervous system are infiltrated by malignant lymphocytes. Rarely, it may be the presenting feature of recurrence of lymphoma otherwise deemed to be in remission. It is crucial, as is the case with all types of nodal or visceral involvement of lymphoma, to identify the disease early and initiate treatment with chemotherapy and/or radiation therapy. Positron emission tomography-computed tomography (PET-CT) has been shown to be a sensitive modality for staging, restaging, biopsy guidance, therapy response assessment, and surveillance for recurrence of lymphoma. Magnetic resonance imaging (MRI) is another useful imaging modality, which, along with PET/CT, compliment cerebrospinal spinal fluid (CSF) cytology and electromyography (EMG) in the diagnosis of NL. Performing nerve biopsies to confirm neurolymphomatosis can be challenging and with associated morbidity. The case presented herein illustrates the practical usefulness of these tests in detecting NL as a heralding feature of lymphoma recurrence, especially in the absence of histopathologic correlation.
机译：神经淋巴瘤病（NL）是与淋巴瘤相关的罕见疾病，其中神经系统的各种结构被恶性淋巴细胞浸润。罕见地，它可能是淋巴瘤复发的表现特征，否则被认为已缓解。与所有类型淋巴瘤的淋巴结或内脏受累一样，至关重要的是及早发现疾病并开始用化学疗法和/或放射疗法进行治疗。正电子发射断层扫描计算机断层扫描（PET-CT）已被证明是用于分期，重新分期，活组织检查指导，治疗反应评估和监视淋巴瘤复发的敏感方式。磁共振成像（MRI）是另一种有用的成像方式，与PET / CT一起，可补充脑脊髓液（CSF）的细胞学检查和肌电图（EMG）在NL诊断中的作用。进行神经活检以确认神经淋巴瘤病可能具有挑战性并伴有发病。本文介绍的病例说明了这些检测在检测NL作为淋巴瘤复发的先兆特征时的实用性，特别是在没有组织病理学相关性的情况下。

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