首页> 美国卫生研究院文献>other >Loss of CCR2 Expressing Non-Classical Monocytes are Associated with Cognitive Impairment in Antiretroviral Therapy-Naïve HIV-Infected Thais
【2h】

Loss of CCR2 Expressing Non-Classical Monocytes are Associated with Cognitive Impairment in Antiretroviral Therapy-Naïve HIV-Infected Thais

机译:表达CCR2的非经典单核细胞的丢失与抗逆转录病毒疗法未受过艾滋病毒感染的泰国人的认知障碍相关

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

HIV DNA in monocytes has been linked to HIV-associated neurocognitive disorders (HAND), however, characterization of monocyte subsets associated with HAND remains unclear. We completed a prospective study of antiretroviral therapy-naïve, HIV-infected Thais, with varying degrees of cognitive impairment, compared to HIV-uninfected controls. Monocyte subsets’ CCR2, CCR5 and CD163 expression were profiled and inflammatory markers in plasma and cerebrospinal fluid (CSF), measured. Lower numbers of CCR2+non-classical monocytes were associated with worse neuropsychological test performance (r=0.43,p=0.024). CCR2+non-classical monocyte count inversely correlated with CSF neopterin (r=−0.43,p=0.035) and plasma TNF-α levels (r=−0.40,p=0.041). These data benchmark CCR2+non-classical monocytes as an independent index of cognitive impairment.
机译:单核细胞中的HIV DNA已与HIV相关的神经认知障碍(HAND)相关联,但是,与HAND相关的单核细胞亚群的表征仍不清楚。与未感染艾滋病毒的对照组相比,我们完成了一项针对未接受过抗逆转录病毒疗法治疗,感染了艾滋病毒的泰国人的前瞻性研究。分析单核细胞亚群的CCR2,CCR5和CD163表达,并测量血浆和脑脊液(CSF)中的炎症标志物。较少的CCR2 + 非经典单核细胞数量与较差的神经心理学测试表现有关(r = 0.43,p = 0.024)。 CCR2 + 非经典单核细胞计数与CSF新蝶呤(r = -0.43,p = 0.035)和血浆TNF-α水平(r = -0.40,p = 0.041)呈负相关。这些数据将CCR2 + 非经典单核细胞作为认知障碍的独立指标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号