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Role of the Bed Nucleus of the Stria Terminalis in the Acquisition of Contextual Fear at Long or Short Context-Shock Intervals

机译：终端纹状体床核在长或短情境-冲击间隔中对情境恐惧的获取中的作用

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摘要

Rats received NMDA lesions of the bed nucleus of the stria terminalis (BNST) and then ten aversive conditioning trials in which exposure to a context was paired with footshock. For half the animals, shock was presented one minute after the onset of each context exposure; for the other half, shock was presented after 10 minutes. With the one-min context duration, aversive conditioning (measured by freezing) was unaffected by BNST lesion. In contrast, at the 10-min duration, lesioned animals froze substantially less than sham controls. When one-minute-conditioned animals were left in the context for 10 minutes, freezing that was evident (though declining) throughout the test was not affected by the BNST lesion. When freezing over 10 mins was similarly examined in the 10-min-conditioned animals, BNST lesions caused a deficit that was consistently evident over time. The results indicate that the BNST is involved in aversive conditioning to long-duration, but not merely contextual, conditional stimuli. Results may be less consistent with the view that BNST becomes activated after prolonged fear than the view that it is involved when a cue’s onset has a remote temporal relation to shock.
机译：大鼠接受了纹状体床床底核（BNST）的NMDA损伤，然后进行了十次厌恶性适应性试验，其中暴露于环境中与足部震颤配对。对于一半的动物，每次环境暴露开始后一分钟出现电击。对于另一半，在10分钟后出现电击。在1分钟的背景持续时间内，厌恶性条件（通过冷冻测量）不受BNST病变的影响。相比之下，在10分钟的持续时间内，患病动物的冻结现象明显少于假对照组。当在一分钟条件下的动物在环境中放置10分钟时，在整个测试过程中明显（虽然下降）的冰冻不受BNST病变的影响。在条件为10分钟的动物中类似地检查了10分钟以上的冰冻时，BNST损伤会导致赤字，这种赤字随着时间的推移会持续出现。结果表明，BNST参与了对持续时间的厌恶调节，而不仅仅是上下文的条件刺激。与长时间恐惧后激活BNST的观点相比，提示的结果可能不如提示发生时与电击的短暂时间关系有关。

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