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首页> 美国卫生研究院文献>other >Prevalence of HIV Hepatitis B and C Infections and an Assessment of HCV-Genotypes and Two IL28B SNPs among People Who Inject Drugs in Three Regions of Nepal
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Prevalence of HIV Hepatitis B and C Infections and an Assessment of HCV-Genotypes and Two IL28B SNPs among People Who Inject Drugs in Three Regions of Nepal

机译：尼泊尔三个地区注射毒品的人群中HIV乙肝和丙型肝炎感染率以及HCV基因型和两个IL28B SNP的评估

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As part of a comprehensive health care programme for people who use drugs in Nepal, HIV and viral hepatitis B and C status—including risk factors, HCV-genotypes and co-infections—as well as two IL28B Single-nucleotide polymorphisms (SNPs) were assessed for a random sample of 401 people who inject drugs in three regions of Nepal: mid-western Terrai (Nepalgunj), the eastern region (Dharan, Biratnagar) and the central region (Kathmandu, Lalitpur and Chitwan). Individuals were included who showed at least a minimum of health care seeking behaviour. This latter criterion was defined by being registered with any organisation offering health services. The average age of the participants was 30.5 yrs, and the average length of intravenous drug use was 8.5 yrs. The prevalence rates of HBsAg, anti-HIV antibodies and HCV-RNA were 3.5%, 13.8% and 41.9%, respectively. Spontaneous HCV clearance was evident in 16% of all of those who tested positive for anti-HCV antibodies. Independent risk factors for HCV-RNA positivity were age, gender, geographical region, duration of injecting drug use, history of imprisonment and HIV co-infection. In the age group ≤24 yrs, the rate of spontaneous HCV clearance was 43.5%. Overall, 59.8% of HCV infections were caused by HCV genotype 3 and 40.2% by HCV genotype 1. No other HCV genotypes were identified in this study. The IL28B SNP rs12979860 and rs8099917 were identified in 122 patients, and 75.4% of all participants had both favourable genotypes rs12979860 C/C and rs8099917 T/T.
机译：作为针对在尼泊尔使用毒品的人的全面医疗保健计划的一部分，HIV和病毒性乙型和丙型肝炎的状态（包括危险因素，HCV基因型和合并感染）以及两种IL28B单核苷酸多态性（SNP）在尼泊尔三个中部地区（Nepalgunj），东部地区（Dharan，Biratnagar）和中部地区（加德满都，拉利特布尔和奇旺）的401人中随机抽取了401人进行毒品注射。包括至少表现出最少医疗保健行为的个人。后一个标准是通过在提供卫生服务的任何组织中注册而定义的。参与者的平均年龄为30.5岁，静脉注射毒品的平均时间为8.5岁。 HBsAg，抗HIV抗体和HCV-RNA的患病率分别为3.5％，13.8％和41.9％。在抗HCV抗体检测呈阳性的所有患者中，有16％的患者自发HCV清除率很明显。 HCV-RNA阳性的独立危险因素是年龄，性别，地理区域，注射毒品的持续时间，入狱史和HIV合并感染。 ≤24岁年龄组的HCV自发清除率为43.5％。总体而言，HCV感染的59.8％是由HCV基因型3引起的，而40.2％是由HCV基因型1引起的。在本研究中未发现其他HCV基因型。在122例患者中鉴定出IL28B SNP rs12979860和rs8099917，所有参与者中的75.4％具有良好的rs12979860 C / C和rs8099917 T / T基因型。

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