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Restoration of middle-ear input in fluid-filled middle ears by controlled introduction of air or a novel air-filled implant

机译：通过控制引入空气或新型充气植入物来恢复充液中耳的中耳输入

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The effect of small amounts of air on sound-induced umbo velocity in an otherwise saline-filled middle ear (ME) was investigated to examine the efficacy of a novel balloon-like air-filled ME implant suitable for patients with chronically non-aerated MEs. In this study, air bubbles or air-filled implants were introduced into saline-filled human cadaveric MEs. Umbo velocity, a convenient measure of ME response, served as an indicator of hearing sensitivity. Filling the ME with saline reduced umbo velocity by 25–30 dB at low frequencies and more at high frequencies, consistent with earlier work (Ravicz et al., Hear. Res. 195: 103–130 (2004)). Small amounts of air (~30 μl) in the otherwise saline-filled ME increased umbo velocity substantially, to levels only 10–15 dB lower than in the dry ME, in a frequency- and location-dependent manner: air in contact with the tympanic membrane (TM) increased umbo velocity at all frequencies, while air located away from the TM increased umbo velocity only below about 500 Hz. The air-filled implant also affected umbo velocity in a manner similar to an air bubble of equivalent compliance. Inserting additional implants into the ME had the same effect as increasing air volume. These results suggest these middle-ear implants would significantly reduce conductive hearing loss in patients with chronically fluid-filled MEs.
机译：研究了少量空气对否则充满盐的中耳（ME）中声诱发的超音速的影响，以研究适用于慢性非充气性ME患者的新型气球状充气ME植入物的功效。在这项研究中，将气泡或充气植入物引入了充满盐水的人体尸体ME中。超音速是衡量ME反应的便捷方法，可作为听觉敏感性的指标。用生理盐水填充ME可以使低频处的超音速降低25–30 dB，而在高频处降低更多，这与早期的工作是一致的（Ravicz等人，Hear。Res。195：103–130（2004））。否则，充满盐水的ME中的少量空气（〜30μl）显着提高了超音速，其频率仅取决于干燥的ME，且仅依赖于频率和位置，降低了10–15 dB：鼓膜（TM）在所有频率下都增加了超音速，而远离TM的空气仅在约500 Hz以下才增加了超音速。充满空气的植入物还以与等效顺应性气泡类似的方式影响了超音速。将额外的植入物插入ME具有与增加风量相同的效果。这些结果表明，这些中耳植入物将显着减少患有慢性充液性ME的患者的传导性听力损失。

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