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首页> 美国卫生研究院文献>other >Dietary Lipid Levels Influence Lipid Deposition in the Liver of Large Yellow Croaker (Larimichthys crocea) by Regulating Lipoprotein Receptors Fatty Acid Uptake and Triacylglycerol Synthesis and Catabolism at the Transcriptional Level
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Dietary Lipid Levels Influence Lipid Deposition in the Liver of Large Yellow Croaker (Larimichthys crocea) by Regulating Lipoprotein Receptors Fatty Acid Uptake and Triacylglycerol Synthesis and Catabolism at the Transcriptional Level

机译：饮食中的脂质水平通过调节转录水平上的脂蛋白受体脂肪酸摄取和三酰甘油合成及分解代谢影响大黄鱼（Larimichthys crocea）肝脏中的脂质沉积。

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Ectopic lipid accumulation has been observed in fish fed a high-lipid diet. However, no information is available on the mechanism by which dietary lipid levels comprehensively regulate lipid transport, uptake, synthesis and catabolism in fish. Therefore, the present study aimed to gain further insight into how dietary lipids affect lipid deposition in the liver of large yellow croaker(Larimichthys crocea). Fish (150.00±4.95 g) were fed a diet with a low (6%), moderate (12%, the control diet) or high (18%) crude lipid content for 10 weeks. Growth performance, plasma biochemical indexes, lipid contents and gene expression related to lipid deposition, including lipoprotein assembly and clearance, fatty acid uptake and triacylglycerol synthesis and catabolism, were assessed. Growth performance was not significantly affected. However, the hepato-somatic and viscera-somatic indexes as well as plasma triacylglycerol, non-esterified fatty acids and LDL-cholesterol levels were significantly increased in fish fed the high-lipid diet. In the livers of fish fed the high-lipid diet, the expression of genes related to lipoprotein clearance (LDLR) and fatty acid uptake (FABP11) was significantly up-regulated, whereas the expression of genes involved in lipoprotein assembly (apoB100), triacylglycerol synthesis and catabolism (DGAT2, CPT I) was significantly down-regulated compared with fish fed the control diet, and hepatic lipid deposition increased. In fish fed the low-lipid diet, the expression of genes associated with lipoprotein assembly and clearance (apoB100, LDLR, LRP-1), fatty acid uptake (CD36, FATP1, FABP3) and triacylglycerol synthesis (FAS) was significantly increased, whereas the expression of triacylglycerol catabolism related genes (ATGL, CPT I) was reduced compared with fish fed the control diet. However, hepatic lipid content in fish fed the low-lipid diet decreased mainly due to low dietary lipid intake. In summary, findings of this study provide molecular insight into the role of lipid deposition in the liver in response to different dietary lipid contents.
机译：在高脂饮食的鱼中观察到异位脂质蓄积。但是，尚无关于饮食脂质水平全面调节鱼中脂质运输，摄取，合成和分解代谢的机理的信息。因此，本研究旨在进一步了解饮食中的脂质如何影响大黄鱼（Larimichthys crocea）肝脏中的脂质沉积。鱼（150.00±4.95 g）的粗脂肪含量低（6％），中度（对照饮食为12％）或高（18％）为饮食，持续10周。评估了生长性能，血浆生化指标，脂质含量和与脂质沉积相关的基因表达，包括脂蛋白组装和清除，脂肪酸摄取以及三酰甘油的合成和分解代谢。生长性能未受到明显影响。然而，饲喂高脂饮食的鱼肝，体，内脏指数以及血浆三酰甘油，非酯化脂肪酸和低密度脂蛋白胆固醇水平显着增加。在高脂饮食的鱼肝中，与脂蛋白清除（LDLR）和脂肪酸摄取（FABP11）相关的基因表达明显上调，而与脂蛋白组装（apoB100），三酰甘油有关的基因表达与饲喂对照饮食的鱼相比，其合成和分解代谢（DGAT2，CPT I）显着下调，肝脂质沉积增加。在喂食低脂饮食的鱼中，与脂蛋白组装和清除（apoB100，LDLR，LRP-1），脂肪酸摄取（CD36，FATP1，FABP3）和三酰甘油合成（FAS）相关的基因表达显着增加，而与饲喂对照饮食的鱼相比，三酰甘油分解代谢相关基因（ATGL，CPT I）的表达降低。然而，饲喂低脂饮食的鱼肝脂质含量下降，主要是由于低脂饮食。总而言之，这项研究的发现提供了分子内对于脂质沉积在肝脏中对不同饮食脂质含量的响应的作用的分子见解。

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