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首页> 美国卫生研究院文献>other >The CODAtwins project: the cohort description of COllaborative project of Development of Anthropometrical measures in Twins to study macro-environmental variation in genetic and environmental effects on anthropometric traits
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The CODAtwins project: the cohort description of COllaborative project of Development of Anthropometrical measures in Twins to study macro-environmental variation in genetic and environmental effects on anthropometric traits

机译：CODAtwins项目：Twins人体测量学发展合作项目的队列描述以研究遗传和环境对人体测量特征的宏观环境变异

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For over one hundred years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m2) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically 1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and 2) to study the effects of birth related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects including both monozygotic and dizygotic twins using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes.
机译：一百多年来，人类人体测量学特征的遗传学引起了科学兴趣。尤其是身高体重指数（BMI，以kg / m 2 计算）正在深入的遗传研究中。但是，人们之间的遗传力估计值是否以及如何变化仍是未知之数。由于建立了许多新的双生代队列并且已建立的双生代队列中的数据积累不断增加，解决这个问题的机会最近有所增加。我们开始了一个新的研究项目，以系统地分析1）出生人群，种族和国家之间的身高，身高体重指数及其轨迹的遗传估计值的变化，以及2）研究与出生有关的因素，教育和吸烟的影响这些人体测量学特征，以及这些影响是否在双胞胎队列之间有所不同。我们使用各种来源确定了67个双胞胎项目，包括单卵双卵和双卵双卵。我们要求提供有关身高和体重的个人水平数据，包括重复测量，与出生相关的特征，背景变量，教育程度和吸烟情况。截至2014年底，参与项目48个。我们总共有来自434,723对双胞胎个体的893,458身高和体重测量值（女性占52％），包括代表22个国家的201,192对完整的双胞胎（40％单卵，40％同性双卵和20％异性双卵）。该项目表明，大规模的国际双生子研究是可行的，并且可以促进将现有数据用于新颖的研究目的。

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