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Phase I/II Trial of Paclitaxel Plus Ifosfamide Followed by High-Dose Paclitaxel Ifosfamide and Carboplatin (TI-TIC) with Autologous Stem Cell Reinfusion for Salvage Treatment of Germ Cell Tumors

机译：紫杉醇加异环磷酰胺的I / II期试验然后进行大剂量紫杉醇异环磷酰胺和卡铂（TI-TIC）结合自体干细胞回输以挽救治疗生殖细胞肿瘤

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PurposeSalvage high-dose chemotherapy with autologous stem cell transplant (ASCT), consisting of 2–3 sequential cycles of high-dose (HD) carboplatin and etoposide (CE) can achieve durable remissions in approximately one-half of relapsed germ cell tumor patients. To improve upon these results and based on success with paclitaxel, ifosfamide, and cisplatin (TIP) as salvage conventional-dose chemotherapy, we conducted a phase I/II trial of HD paclitaxel plus ifosfamide (TI), substituting carboplatin for cisplatin to allow dose escalation.

机译：目的采用自体干细胞移植（ASCT）进行大剂量化疗，由高剂量（HD）卡铂和依托泊苷（CE）的2至3个连续周期组成，可在大约一半的复发性生殖细胞肿瘤患者中实现持久缓解。为了改善这些结果，并基于紫杉醇，异环磷酰胺和顺铂（TIP）挽救常规剂量化疗的成功，我们进行了HD紫杉醇加异环磷酰胺（TI）的I / II期试验，用卡铂代替顺铂以允许剂量升级。

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期刊名称 other
作者
Darren R. Feldman; Ilya Glezerman; Sujata Patil; Lindsay Van Alstine; Dean F. Bajorin; Patricia Fischer; Amanad Hughes; Joel Sheinfeld; Manjit Bains; Lilian Reich; Kaitlin Woo; Sergio Giralt; George J. Bosl; Robert J. Motzer;
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年(卷),期 -1(13),5
年度 -1
页码 453–460
总页数 17
原文格式 PDF
正文语种
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关键词
high-dose chemotherapy autologous stem cell support nephrotoxicity testicular cancer;

机译：大剂量化疗;自体干细胞支持;肾毒性;睾丸癌;

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专利

1. 紫杉醇、卡铂方案与异环磷酰胺、鬼臼乙叉甙、卡铂方案治疗晚期非小细胞肺癌的比较 [J] . 李德宪, 陈小冰癌症（英文版） . 2002,第004期
2. Salvage treatment with paclitaxel, ifosfamide, and cisplatin plus high-dose carboplatin, etoposide, and thiotepa followed by autologous stem-cell rescue in patients with relapsed or refractory germ cell cancer. [J] . Rick O, Bokemeyer C, Beyer J, Journal of Clinical Oncology . 2001,第1期

机译：在复发或难治性生殖细胞癌患者中，使用紫杉醇，异环磷酰胺和顺铂加大剂量卡铂，依托泊苷和噻替帕进行挽救治疗，然后进行自体干细胞抢救。
3. Paclitaxel plus Ifosfamide followed by high-dose carboplatin plus etoposide in previously treated germ cell tumors. [J] . Kondagunta GV, Bacik J, Sheinfeld J, Journal of Clinical Oncology . 2007,第1期

机译：在先前治疗的生殖细胞肿瘤中，紫杉醇加异环磷酰胺，然后大剂量卡铂加依托泊苷。
4. A phase II trial of TIP (paclitaxel, ifosfamide and cisplatin) given as second-line (post-BEP) salvage chemotherapy for patients with metastatic germ cell cancer: a medical research council trial Mead GM, Cullen MH, Huddart R, Harper P, Rustin GJ, Co [J] . Richie JP Urologic oncology . 2006,第2期

机译：TIP（紫杉醇，异环磷酰胺和顺铂）的II期临床试验作为转移性生殖细胞癌患者的二线（BEP后）挽救性化疗：医学研究理事会的一项试验Mead GM，Cullen MH，Huddart R，Harper P， Rustin GJ，Co
5. Is High-Dose Chemotherapy Plus Stem-Cell Transplant the Standard Treatment for Patients Failing First-Line Chemotherapy for Metastatic Germ Cell Tumor? [C] . Christian Kollmannsberger, Lawrence Einhorn, Craig Nichols Genitourinary Cancers Symposium. . 2014

机译：高剂量化疗加干细胞移植对转移细胞肿瘤的一线化疗失败的患者的标准治疗吗？
6. Safety and Efficacy of the Immunomodulatory Drug (IMiD) Lenalidomide in Patients with Lymphoma: Development of RU051417I - Phase I/II Open-Label Study of R-ICE (Rituximab-Ifosfamide-Carboplatin-Etoposide) with Lenalidomide [R2-ICE] in Patients with First-Relapse/Primary Refractory Diffuse Large B-Cell Lymphoma (DLBCL). [D] . Kasi, Pashtoon Murtaza. 2018

机译：免疫调节药物来那度胺在淋巴瘤患者中的安全性和有效性：RU051417I-R-ICE（利妥昔单抗-异环磷酰胺-卡铂-依托泊苷）与来那度胺[R2-ICE]的I / II期开放标签研究的进展初次复发/原发性难治性弥漫性大B细胞淋巴瘤（DLBCL）。
7. A phase II trial of TIP (paclitaxel ifosfamide and cisplatin) given as second-line (post-BEP) salvage chemotherapy for patients with metastatic germ cell cancer: a medical research council trial [O] . G M Mead, M H Cullen, R Huddart, 2005

机译：TIP（紫杉醇异环磷酰胺和顺铂）II期试验作为转移性生殖细胞癌患者的二线（BEP后）挽救性化疗：一项医学研究委员会试验
8. Phase I/II Study of Paclitaxel Plus Ifosfamide Followed By High-Dose Paclitaxel, Ifosfamide, and Carboplatin with Autologous Stem Cell Reinfusion for Salvage Treatment of Germ Cell Tumors [O] . Feldman Darren R., Glezerman Ilya, Patil Sujata, 2014

机译：紫杉醇加异环磷酰胺，大剂量紫杉醇，异环磷酰胺和卡铂联合自体干细胞再灌注用于挽救生殖细胞肿瘤的I / II期研究

Phase I/II Trial of Paclitaxel Plus Ifosfamide Followed by High-Dose Paclitaxel Ifosfamide and Carboplatin (TI-TIC) with Autologous Stem Cell Reinfusion for Salvage Treatment of Germ Cell Tumors

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