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Bombesin preserves goblet cell resistin-like molecule beta during parenteral nutrition but not other goblet cell products

机译：肠溶营养期间Bombesin保留杯状细胞抵抗素样分子β但其他杯状细胞产品则不保留

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IntroductionParenteral nutrition (PN) increases the risk of infection in critically ill patients and is associated with defects in gastrointestinal innate immunity. Goblet cells produce mucosal defense compounds including mucin (principally MUC2), trefoil factor 3 (TFF3,) and resistin-like molecule β (RELMβ). Bombesin (BBS), a gastin-releasing peptide analogue, experimentally reverses PN-induced defects in Paneth cell innate immunity. We hypothesized that PN reduces goblet cell product expression and PN+BBS would reverse these PN-induced defects.

机译：简介肠外营养（PN）增加了危重患者的感染风险，并与胃肠道先天免疫缺陷有关。杯状细胞产生粘膜防御化合物，包括粘蛋白（主要是MUC2），三叶因子3（TFF3）和抵抗素样分子β（RELMβ）。 Bombesin（BBS）是一种释放胃泌素的肽类似物，通过实验逆转了PN诱导的Paneth细胞先天性免疫缺陷。我们假设PN会降低杯状细胞产物的表达，而PN + BBS会逆转这些PN诱导的缺陷。

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期刊名称 other
作者
Rebecca A. Busch; Aaron F. Heneghan; Joseph F. Pierre; Joshua C. Neuman; Claire A. Reimer; Xinying Wang; Michelle E. Kimple; Kenneth A. Kudsk;
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作者单位

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年(卷),期 -1(40),7
年度 -1
页码 1042–1049
总页数 18
原文格式 PDF
正文语种
中图分类
关键词
Parenteral nutrition enteric nervous system small intestine innate immunity goblet cells mucin 2 trefoil factor 3 resistin-like molecule beta bombesin;

机译：肠胃外营养;肠神经系统;小肠;先天免疫;杯状细胞;粘蛋白2;三叶因子3;抵抗素样分子β;蛙皮素;

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专利

1. Bombesin Preserves Goblet Cell Resistin-Like Molecule During Parenteral Nutrition but Not Other Goblet Cell Products [J] . Busch Rebecca A., Heneghan Aaron F., Pierre Joseph F., JPEN. Journal of parenteral and enteral nutrition. . 2016,第7期

机译：Bombesin在肠胃外营养期间保留类似杯状细胞的抵抗素分子，但不保留其他杯状细胞产品
2. Goblet cell-derived resistin-like molecule beta augments CD4+ T cell production of IFN-gamma and infection-induced intestinal inflammation. [J] . Nair MG, Guild KJ, Du Y, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2008,第7期

机译：杯状细胞来源的抵抗素样分子β增强了IFN-γ的CD4 + T细胞生成和感染引起的肠道炎症。
3. Deoxynivalenol inhibits the expression by goblet cells of intestinal mucins through a PKR and MAP kinase dependent repression of the resistin-like molecule [J] . Pinton Philippe, Graziani Fabien, Pujol Ange, Molecular Nutrition and Food Research . 2015,第6期

机译：脱氧雪腐烯醇通过PKR和MAP激酶依赖性抵抗性抵抗素样分子抑制杯状细胞表达肠粘蛋白
4. Combination of intestinal goblet HT29 and M-like cells with absorptive Caco-2cells to predict oral absorption of nanoparticles containing insulin [C] . C. Gehm, A.P. Neto, J. Fonseca, Annual meeting exposition of the Controlled Release Society . 2009

机译：肠杯HT29和M样细胞与吸收性Caco-2细胞的结合，预测含胰岛素的纳米颗粒的口服吸收
5. Mechanisms of Autophagy Protein Mediated Goblet Cell Secretion in the Intestinal Epithelium. [D] . Patel, Khushbu. 2014

机译：自噬蛋白介导的肠上皮杯状细胞分泌的机制。
6. Goblet Cell-Derived Resistin-Like Molecule β Augments CD4+ T Cell Production of IFN-γ and Infection-Induced Intestinal Inflammation [O] . Meera G. Nair, Katherine J. Guild, Yurong Du, -1

机译：杯状细胞产生的抵抗素样分子β增强了IFN-γ的CD4 + T细胞产生和感染诱导的肠道炎症
7. Goblet Cell-Derived Resistin-Like Molecule β Augments CD4+ T Cell Production of IFN-γ and Infection-Induced Intestinal Inflammation [O] . Meera G. Nair, Katherine J. Guild, Yurong Du, 2008

机译：脚耳细胞衍生的含量样子β增大CD4 + T细胞产生IFN-γ和感染诱导的肠炎

Bombesin preserves goblet cell resistin-like molecule beta during parenteral nutrition but not other goblet cell products

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