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Medical Textiles as Vascular Implants and Their Success to Mimic Natural Arteries

机译:医用纺织品作为血管植入物及其在模仿自然动脉方面的成功

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摘要

Vascular implants belong to a specialised class of medical textiles. The basic purpose of a vascular implant (graft and stent) is to act as an artificial conduit or substitute for a diseased artery. However, the long-term healing function depends on its ability to mimic the mechanical and biological behaviour of the artery. This requires a thorough understanding of the structure and function of an artery, which can then be translated into a synthetic structure based on the capabilities of the manufacturing method utilised. Common textile manufacturing techniques, such as weaving, knitting, braiding, and electrospinning, are frequently used to design vascular implants for research and commercial purposes for the past decades. However, the ability to match attributes of a vascular substitute to those of a native artery still remains a challenge. The synthetic implants have been found to cause disturbance in biological, biomechanical, and hemodynamic parameters at the implant site, which has been widely attributed to their structural design. In this work, we reviewed the design aspect of textile vascular implants and compared them to the structure of a natural artery as a basis for assessing the level of success as an implant. The outcome of this work is expected to encourage future design strategies for developing improved long lasting vascular implants.
机译:血管植入物属于医学纺织品的特殊类别。血管植入物(移植物和支架)的基本目的是充当人造导管或替代患病的动脉。但是,长期愈合功能取决于其模仿动脉机械和生物学行为的能力。这需要对动脉的结构和功能有透彻的了解,然后可以根据所用制造方法的能力将其转化为合成结构。在过去的几十年中,常见的纺织品制造技术(例如织造,编织,编织和静电纺丝)经常用于设计用于研究和商业目的的血管植入物。然而,将血管替代物的属性与天然动脉的属性进行匹配的能力仍然是一个挑战。已发现合成植入物在植入部位引起生物学,生物力学和血液动力学参数的紊乱,这被广泛地归因于其结构设计。在这项工作中,我们回顾了纺织血管植入物的设计方面,并将它们与天然动脉的结构进行了比较,以此作为评估植入物成功与否的基础。预期这项工作的结果将鼓励未来的设计策略,以开发改进的持久性血管植入物。

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