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Association between rs7517847 and rs2201841 polymorphisms in IL-23 receptor gene and risk of ankylosing spondylitis: a meta-analysis

机译：IL-23受体基因中rs7517847和rs2201841多态性与强直性脊柱炎风险的关联：一项荟萃分析

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To comprehensively evaluate the association between rs7517847 and rs2201841 polymorphisms in the Interleukin-23 (IL-23) receptor gene and ankylosing spondylitis (AS), a meta-analysis was performed. The Pubmed, Embase, MEDLINE, Cochrane, China National Knowledge Infrastructure (CNKI), VIP, Wanfang and China Biology Medicine disc (CBMdisc) databases were searched to identify eligible studies on rs7517847 and rs2201841 polymorphisms in the IL-23 receptor gene and AS that were published through September 2014. Data of interest were extracted from each study, and the meta-analysis was performed using STATA 12.0. Four studies were eligible for the meta-analysis and included a total patient population of 2,465. With regards to rs7517847, the current study showed that the genotype GG and allele G might play a protective role during AS (OR = 0.76, 95% CI [0.59–0.99]; OR = 0.88, 95% CI [0.78–0.99] for homozygote and allelic models, respectively). However, according to the meta-analysis, there was no statistical association between the genotype or allele of rs2201841 and an individual’s susceptibility to AS in all genetic models. In conclusion, it was the IL-23 rs7517847 polymorphism rather than the rs2201841 polymorphism that had a statistical association with AS. Nevertheless, more evidence is needed to confirm this result. Consequently, it is necessary to carry out more high-quality studies to confirm the associations between these two single nucleotide polymorphisms and AS.
机译：为了全面评估白介素23（IL-23）受体基因中的rs7517847和rs2201841多态性与强直性脊柱炎（AS）之间的关联，进行了荟萃分析。搜索Pubmed，Embase，MEDLINE，Cochrane，中国国家知识基础设施（CNKI），VIP，万方和中国生物医学光盘（CBMdisc）数据库，以鉴定有关IL-23受体基因和AS中rs7517847和rs2201841多态性的合格研究。该研究的截止日期为2014年9月。每项研究均提取了感兴趣的数据，并使用STATA 12.0进行了荟萃分析。有四项研究符合荟萃分析的条件，包括2465名患者。关于rs7517847，当前研究表明，基因型GG和等位基因G可能在AS期间起保护作用（OR = 0.76，95％CI [0.59-0.99]； OR = 0.88，95％CI [0.78-0.99]）。纯合子和等位基因模型）。但是，根据荟萃分析，在所有遗传模型中，rs2201841的基因型或等位基因与个体对AS的易感性之间没有统计关联。总之，与AS具有统计学关联的是IL-23 rs7517847多态性，而不是rs2201841多态性。然而，需要更多的证据来证实这一结果。因此，有必要进行更多高质量的研究，以确认这两个单核苷酸多态性与AS之间的关联。

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