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Catheter-based ultrasound technology for image-guided thermal therapy: Current technology and applications

机译:用于图像引导热疗法的基于导管的超声技术:当前技术和应用

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摘要

Catheter-based ultrasound (CBUS) is being applied to deliver minimally invasive thermal therapy to solid cancer tumors, benign tissue growth, vascular disease, and tissue remodeling. Compared to other energy modalities used in catheter-based surgical interventions, unique features of ultrasound result in conformable and precise energy delivery with high selectivity, fast treatment times, and larger treatment volumes. Here, a concise review of CBUS technology being currently utilized in animal and clinical studies or being developed for future applications is presented. CBUS devices have been categorized into interstitial, endoluminal and endovascular/cardiac applications. Basic applicator designs, site specific evaluations and possible treatment applications have been discussed in brief. Particular emphasis has been given on ablation studies that incorporate image-guidance for applicator placement, therapy monitoring, feedback control, and post-procedure assessment. Examples of devices included here span the entire spectrum of development cycle from preliminary simulation based design studies to implementation in clinical investigations. The use of CBUS under image guidance has the potential for significantly improving precision and applicability of thermal therapy delivery.
机译:基于导管的超声(CBUS)被用于为实体癌肿瘤,良性组织生长,血管疾病和组织重塑提供微创热疗法。与基于导管的外科手术中使用的其他能量模式相比,超声的独特功能可产生具有高选择性,快速治疗时间和更大治疗量的一致而精确的能量输送。在此,简要介绍了当前在动物和临床研究中使用或正在为未来应用开发的CBUS技术。 CBUS设备已分为间质性,腔内性和血管内/心脏性应用。简要讨论了基本的喷头设计,针对具体地点的评估以及可能的治疗应用。特别强调了消融研究,该研究结合了图像指导用于涂药器放置,治疗监测,反馈控制和术后评估。这里包括的设备示例涵盖了从基于初步仿真的设计研究到临床研究实施的整个开发周期。在图像指导下使用CBUS可能会显着提高热疗交付的准确性和适用性。

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