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Association between Thiopurine S-methyltransferase Polymorphisms and Thiopurine-Induced Adverse Drug Reactions in Patients with Inflammatory Bowel Disease: A Meta-Analysis

机译：炎症性肠病患者硫嘌呤S-甲基转移酶多态性与硫嘌呤诱导的不良药物反应之间的关联：荟萃分析

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PurposeThiopurine drugs are well established treatments in the management of inflammatory bowel disease (IBD), but their use is limited by significant adverse drug reactions (ADRs). Thiopurine S-methyltransferase (TPMT) is an important enzyme involved in thiopurine metabolism. Several clinical guidelines recommend determining TPMT genotype or phenotype before initiating thiopurine therapy. Although several studies have investigated the association between TPMT polymorphisms and thiopurine-induced ADRs, the results are inconsistent. The purpose of this study is to evaluate whether there is an association between TPMT polymorphisms and thiopurine-induced ADRs using meta-analysis.

机译：目的硫嘌呤类药物是控制炎症性肠病（IBD）的成熟方法，但其使用受到严重的药物不良反应（ADR）的限制。硫嘌呤S-甲基转移酶（TPMT）是参与硫嘌呤代谢的重要酶。一些临床指南建议在开始硫嘌呤治疗之前确定TPMT基因型或表型。尽管有几项研究调查了TPMT多态性与硫嘌呤诱导的ADR之间的关系，但结果并不一致。这项研究的目的是通过荟萃分析评估TPMT多态性与硫嘌呤诱导的ADR之间是否存在关联。

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Yue-Ping Liu; Hai-Yan Wu; Xiang Yang; Han-Qing Xu; Yong-Chuan Li; Da-Chuan Shi; Jun-Fu Huang; Qing Huang; Wei-Ling Fu;
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年(卷),期 -1(10),3
年度 -1
页码 e0121745
总页数 12
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1. Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism. [J] . Schwab M, Schaffeler E, Marx C, Pharmacogenetics . 2002,第6期

机译：硫唑嘌呤治疗和炎性肠病患者的药物不良反应：硫嘌呤S-甲基转移酶多态性的影响。
2. Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment. [J] . Uchiyama K, Nakamura M, Kubota T Journal of gastroenterology . 2009,第3期

机译：日本炎性肠病患者中硫硫嘌呤S-甲基转移酶和肌苷三磷酸焦磷酸水解酶基因的不良反应由硫唑嘌呤/ 6-巯基嘌呤治疗引起。
3. Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment [J] . Kan Uchiyama, Makoto Nakamura, Takahiro Kubota, Journal of Gastroenterology . 2009,第3期

机译：日本炎性肠病患者硫硫嘌呤S-甲基转移酶和肌苷三磷酸焦磷酸水解酶基因的不良反应是由硫唑嘌呤/ 6-巯基嘌呤治疗引起的
4. Natural anti-Inflammatory Compounds for the Management and Adjuvant Therapy of Inflammatory Bowel Disease (IBD) and its Drug Delivery System(DDS) for Targeted to Colon. [C] . Annual meeting exposition of the Controlled Release Society . 2009

机译：用于炎症性肠病（IBD）的管理和佐剂治疗的天然抗炎化合物及其药物递送系统（DDS）用于靶向结肠。
5. Significance of the wingless-type/beta-catenin signaling cascade for cancer risk in inflammatory bowel disease: Association of genetic polymorphism in human dishevelled 1 with dysplasia in ulcerative colitis. [D] . Uthoff, Sonja Martina Stefanie. 2004

机译：无翼型/β-连环蛋白信号传导级联对于炎症性肠病的癌症风险的意义：人类衣衫不整的1的遗传多态性与溃疡性结肠炎的不典型增生相关。
6. Association between Thiopurine S-Methyltransferase Polymorphisms and Azathioprine-Induced Adverse Drug Reactions in Patients with Autoimmune Diseases: A Meta-Analysis [O] . Yue-Ping Liu, Han-Qing Xu, Ming Li, 2010

机译：硫嘌呤S-甲基转移酶多态性与硫唑嘌呤诱发自身免疫性疾病患者药物不良反应的关联：荟萃分析
7. Association between thiopurine S-methyltransferase polymorphisms and thiopurine-induced adverse drug reactions in patients with inflammatory bowel disease: a meta-analysis. [O] . Yue-Ping Liu, Hai-Yan Wu, Xiang Yang, 2015

机译：炎症性肠病患者中硫嘌呤s-甲基转移酶基因多态性与硫嘌呤诱导的药物不良反应的关联：荟萃分析。

Association between Thiopurine S-methyltransferase Polymorphisms and Thiopurine-Induced Adverse Drug Reactions in Patients with Inflammatory Bowel Disease: A Meta-Analysis

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