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首页> 美国卫生研究院文献>Journal of the Experimental Analysis of Behavior >Relative reinforcer magnitude under a nonindependent concurrent schedule of cocaine reinforcement in rhesus monkeys.
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Relative reinforcer magnitude under a nonindependent concurrent schedule of cocaine reinforcement in rhesus monkeys.

机译：恒河猴非可卡因非同期并行给药方案下的相对增强剂强度。

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摘要

Lever pressing by three rhesus monkeys was maintained under a two-lever concurrent schedule of cocaine reinforcement. Responding on one lever (constant-dose lever) produced a constant dose of 0.05 or 0.1 mg/kg/injection arranged according to a variable-interval 1-min schedule. Responding on the other lever (variable-dose lever) produced a comparison dose of cocaine (0.013 to 0.8 mg/kg/injection), also under a variable-interval 1-min schedule. The two variable-interval schedules were made nonindependent by arranging that the assignment of a reinforcer by one schedule inactivated the second schedule until the assigned reinforcer had been obtained. This modification ensured that the two cocaine doses were obtained with approximately equal frequency, regardless of the distribution of the subject's responding. Preference, indicated by relative response frequency on the variable-dose lever, was almost always for the larger of the doses and was a monotonic function of the comparison dose, except at the highest doses. Preferences at the highest comparison doses may have resulted from the low overall response rates exhibited at these doses. Relative response frequencies on the variable-dose lever roughly matched relative reinforcer magnitude (mg/kg/injection available on the variable-dose lever divided by the sum of mg/kg/injections available on each lever).
机译：三只恒河猴的杠杆压制是在两杠杆同时进行可卡因强化的情况下进行的。响应一个杠杆（恒定剂量杠杆），可产生0.05或0.1 mg / kg / kg的恒定剂量，并按照1分钟的可变间隔计划进行。同样在间隔为1分钟的时间表下，对另一个杠杆（可变剂量杠杆）的反应产生了可卡因的比较剂量（0.013至0.8 mg / kg /注射）。通过安排一个调度程序对钢筋的分配使第二个调度无效，直到获得分配的钢筋，使两个可变间隔的调度成为非独立的。这种修饰确保无论受试者反应的分布如何，均以近似相等的频率获得两种可卡因剂量。可变剂量控制杆上的相对响应频率表示的偏爱，几乎总是针对较大剂量，并且是比较剂量的单调函数，但最高剂量除外。在最高比较剂量下的偏爱可能是由于在这些剂量下表现出的总体响应率低。可变剂量杆上的相对响应频率大致与补强剂的相对大小相匹配（可变剂量杆上的mg / kg /注射量除以每个杆上的mg / kg /注射量之和）。

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