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Tissue Specific Simulations of Interstitial Cells of Cajal Networks Using Unstructured Meshes

机译：使用非结构化网格的Cajal网络间质细胞的组织特异性模拟

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摘要

Gastrointestinal motility is facilitated by specialized pacemaker cells called Interstitial Cells of Cajal (ICC). ICC play a critical role in coordinating normal motility and its degradation in the gastrointestinal tract is associated with many functional motility disorders. Nonetheless, the degree of degradation and associated clinical impact remains unclear. Continuum modeling frameworks offers a virtual mean to simulate the electrical activity, and analyze the ICC activity in both normal and diseased states. Confocal images of the ICC networks were obtained from the intestine of normal mice. In this study, a new approach is presented where meshes of ICC networks were generated using a Delaunay triangulation and used to solve finite-element based reaction-diffusion equations describing gastrointestinal electrophysiology. The electrical activity was simulated on the ICC network and solutions were compared to those of a regular mesh based on individual pixel locations. The simulation results showed the proposed approach to be approximately 80% more efficient than a pixel-based mesh. The difference in activation time for the entire network between the different methods was observed to be around 4% (about 20 ms). The proposed approach will enable efficient examination of the ICC slow wave activity in larger networks and for longer temporal duration that has been previously impossible. This will provide valuable insights relating ICC degradation to gastrointestinal motility disorders.
机译：称为Cajal间质细胞（ICC）的专用起搏器细胞可促进胃肠蠕动。 ICC在协调正常运动中起着关键作用，其在胃肠道中的降解与许多功能性运动障碍有关。尽管如此，降解程度和相关的临床影响仍不清楚。连续谱建模框架提供了一种虚拟手段来模拟电活动，并分析正常和患病状态下的ICC活动。 ICC网络的共聚焦图像是从正常小鼠的肠道中获得的。在这项研究中，提出了一种新方法，其中使用Delaunay三角剖分生成ICC网络的网格，并用于求解基于有限元的描述胃肠道电生理反应扩散方程。在ICC网络上模拟了电活动，并根据单个像素位置将解决方案与常规网格的电活动进行了比较。仿真结果表明，所提出的方法比基于像素的网格的效率高出约80％。观察到不同方法之间整个网络的激活时间差异约为4％（约20毫秒）。所提出的方法将使得能够在更大的网络中以及更长的时间持续时间内有效地检查ICC慢波活动，而此前这是不可能的。这将提供有价值的见解，将ICC降解与胃肠动力异常相关。

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