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首页> 美国卫生研究院文献>Human Brain Mapping >Functional Connectivity Associated With Gait Velocity During Walking and Walking-While-Talking in Aging: A Resting-State fMRI Study
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Functional Connectivity Associated With Gait Velocity During Walking and Walking-While-Talking in Aging: A Resting-State fMRI Study

机译：步态和步态时步态时步态速度相关的功能连接性：静态fMRI研究。

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Gait decline is common among older adults and is a risk factor for adverse outcomes. Poor gait performance in dual-task conditions, such as walking while performing a secondary cognitive interference task, is associated with increased risk of frailty, disability, and death. Yet, the functional neural substrates that support locomotion are not well established. We examined the functional connectivity associated with gait velocity in single- (normal pace walking) and dual-task (walking while talking) conditions using resting-state functional Magnetic Resonance Imaging (fMRI). We acquired 6 minutes of resting-state fMRI data in 30 cognitively healthy older adults. Independent components analyses were performed to separate resting-state fMRI data into group-level statistically independent spatial components that correlated with gait velocity in single- and dual-task conditions. Gait velocity in both task conditions was associated with similar functional connectivity in sensorimotor, visual, vestibular, and left fronto-parietal cortical areas. Compared to gait velocity in the single-task condition, the networks associated with gait velocity in the dual-task condition were associated with greater functional connectivity in supplementary motor and prefrontal regions. Our findings show that there are partially overlapping functional networks associated with single- and dual-task walking conditions. These initial findings encourage the future use of resting-state fMRI as tool in developing a comprehensive understanding of age-related mobility impairments.
机译：步态下降在老年人中很常见，并且是不良后果的危险因素。在双任务条件下（如在执行次要的认知干预任务时走路）步态不佳会增加身体虚弱，残疾和死亡的风险。然而，支持运动的功能性神经底物尚未很好地建立。我们使用静止状态功能磁共振成像（fMRI）研究了在单步（正常步速行走）和双任务（说话时行走）条件下与步态速度相关的功能连接性。我们在30名认知健康的老年人中获得了6分钟的静息状态fMRI数据。进行了独立的成分分析，以将静止状态的fMRI数据分为与单任务和双任务条件下的步态速度相关的组级统计独立的空间成分。在两种工作条件下的步态速度都与感觉运动，视觉，前庭和左额顶皮质区域的相似功能连通性相关。与单任务条件下的步态速度相比，与双任务条件下的步态速度相关的网络在辅助运动和前额叶区域中具有更大的功能连通性。我们的发现表明，与单任务和双任务步行条件相关的功能网络存在部分重叠。这些初步发现鼓励未来将静止状态功能磁共振成像作为工具来发展对与年龄有关的运动障碍的全面理解。

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